The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease

11 Páginas.-- 4 Tablas.-- 2 Figuras

Detalles Bibliográficos
Autores: Rodriguez-Pérez, María Dolores, Santiago-Corral, Laura, Ortega-Hombrados, Laura, Verdugo, Cristina, Arrebola, María Monsalud, Martín-Aurioles, Esther, Fernández-Prior, África, Bermúdez-Oria, Alejandra, De La Cruz, José Pedro, González-Correa, José Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/295664
Acceso en línea:http://hdl.handle.net/10261/295664
https://api.elsevier.com/content/abstract/scopus_id/85146753614
Access Level:acceso abierto
Palabra clave:3′,4′-dihydroxyphenylglycol
Diabetes mellitus
Nephropathy
Oxidative stress
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spelling The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney DiseaseRodriguez-Pérez, María DoloresSantiago-Corral, LauraOrtega-Hombrados, LauraVerdugo, CristinaArrebola, María MonsaludMartín-Aurioles, EstherFernández-Prior, ÁfricaBermúdez-Oria, AlejandraDe La Cruz, José PedroGonzález-Correa, José Antonio3′,4′-dihydroxyphenylglycolDiabetes mellitusNephropathyOxidative stress11 Páginas.-- 4 Tablas.-- 2 FigurasThe aim of this study was to analyze the possible nephroprotective effect of 3',4'-dihydroxyphenylglycol (DHPG), a polyphenolic compound of extra virgin olive oil (EVOO), on renal lesions in an experimental model of type 1 diabetes. Rats were distributed as follows: healthy normoglycemic rats (NDR), diabetic rats treated with saline (DR), and DR treated with 0.5 mg/kg/day or 1 mg/kg/day of DHPG. DR showed a significantly higher serum and renal oxidative and nitrosative stress profile than NDR, as well as reduced prostacyclin production and renal damage (defined as urinary protein excretion, reduced creatinine clearance, increased glomerular volume, and increased glomerulosclerosis index). DHPG reduced the oxidative and nitrosative stress and increased prostacyclin production (a 59.2% reduction in DR and 34.7-7.8% reduction in DHPG-treated rats), as well as 38-56% reduction in urinary protein excretion and 22-46% reduction in glomerular morphological parameters (after the treatment with 0.5 or 1 mg/kg/day, respectively). Conclusions: DHPG administration to type 1-like diabetic rats exerts a nephroprotective effect probably due to the sum of its antioxidant (Pearson's coefficient 0.68-0.74), antinitrosative (Pearson's coefficient 0.83), and prostacyclin production regulator (Pearson's coefficient 0.75) effects.This study was supported, in part, by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud [Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects] (PI-0129-2017).Peer reviewedMultidisciplinary Digital Publishing InstituteJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/295664https://api.elsevier.com/content/abstract/scopus_id/85146753614reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésNutrientshttps://doi.org/10.3390/nu15020377Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2956642026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
title The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
spellingShingle The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
Rodriguez-Pérez, María Dolores
3′,4′-dihydroxyphenylglycol
Diabetes mellitus
Nephropathy
Oxidative stress
title_short The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
title_full The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
title_fullStr The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
title_full_unstemmed The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
title_sort The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease
dc.creator.none.fl_str_mv Rodriguez-Pérez, María Dolores
Santiago-Corral, Laura
Ortega-Hombrados, Laura
Verdugo, Cristina
Arrebola, María Monsalud
Martín-Aurioles, Esther
Fernández-Prior, África
Bermúdez-Oria, Alejandra
De La Cruz, José Pedro
González-Correa, José Antonio
author Rodriguez-Pérez, María Dolores
author_facet Rodriguez-Pérez, María Dolores
Santiago-Corral, Laura
Ortega-Hombrados, Laura
Verdugo, Cristina
Arrebola, María Monsalud
Martín-Aurioles, Esther
Fernández-Prior, África
Bermúdez-Oria, Alejandra
De La Cruz, José Pedro
González-Correa, José Antonio
author_role author
author2 Santiago-Corral, Laura
Ortega-Hombrados, Laura
Verdugo, Cristina
Arrebola, María Monsalud
Martín-Aurioles, Esther
Fernández-Prior, África
Bermúdez-Oria, Alejandra
De La Cruz, José Pedro
González-Correa, José Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 3′,4′-dihydroxyphenylglycol



Diabetes mellitus
Nephropathy
Oxidative stress
topic 3′,4′-dihydroxyphenylglycol
Diabetes mellitus
Nephropathy
Oxidative stress
description 11 Páginas.-- 4 Tablas.-- 2 Figuras
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/295664
https://api.elsevier.com/content/abstract/scopus_id/85146753614
url http://hdl.handle.net/10261/295664
https://api.elsevier.com/content/abstract/scopus_id/85146753614
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nutrients
https://doi.org/10.3390/nu15020377
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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