Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A

[EN] We report herein the design a hybrid material for the recognition of Ochratoxin A (OTA) by using an aptamer gated-material able to release electroactive species, which can be measured using differential pulse voltammetry. Mesoporous silica nanoparticles loaded with Methylene Blue and capped wit...

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Autores: Muthamizh, S., Ribes, Àngela, Anusuyajanakiraman, M., Narayanan, V., Soto Camino, Juan, Martínez-Máñez, Ramón|||0000-0001-5873-9674, Aznar, Elena|||0000-0003-0361-3876
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/102309
Acceso en línea:https://riunet.upv.es/handle/10251/102309
Access Level:acceso abierto
Palabra clave:Molecular gates
Mesoporous materials
Ochratoxin A
Sensing
Differential pulse voltammetry
Electron Microscopy Service of the UPV
QUIMICA INORGANICA
QUIMICA ANALITICA
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network_name_str España
repository_id_str
spelling Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin AMuthamizh, S.Ribes, ÀngelaAnusuyajanakiraman, M.Narayanan, V.Soto Camino, JuanMartínez-Máñez, Ramón|||0000-0001-5873-9674Aznar, Elena|||0000-0003-0361-3876Molecular gatesMesoporous materialsOchratoxin ASensingDifferential pulse voltammetryElectron Microscopy Service of the UPVQUIMICA INORGANICAQUIMICA ANALITICA[EN] We report herein the design a hybrid material for the recognition of Ochratoxin A (OTA) by using an aptamer gated-material able to release electroactive species, which can be measured using differential pulse voltammetry. Mesoporous silica nanoparticles loaded with Methylene Blue and capped with an OTA aptamer were prepared and characterised. A highly selective and sensitive response due to the displacement of the capping aptamer in the presence of OTA and subsequent MB release was found in aqueous media. Finally, the possible use of the gated material for the detection of OTA in a real matrix was also explored.This work was supported by the Spanish Government [project MAT2015-64139-C4-1-R]; the Generalitat Valenciana [project PROMETEOII/2014/047].Taylor & FrancisEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de QuímicaEscuela Técnica Superior de Ingeniería IndustrialInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo TecnológicoGeneralitat ValencianaMinisterio de Economía, Industria y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://riunet.upv.es/handle/10251/102309reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2015-64139-C4-1-R NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICOGeneralitat Valenciana https://doi.org/10.13039/501100003359 PROMETEOII%2F2014%2F047 Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrososopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1023092026-06-13T07:49:27Z
dc.title.none.fl_str_mv Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
title Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
spellingShingle Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
Muthamizh, S.
Molecular gates
Mesoporous materials
Ochratoxin A
Sensing
Differential pulse voltammetry
Electron Microscopy Service of the UPV
QUIMICA INORGANICA
QUIMICA ANALITICA
title_short Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
title_full Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
title_fullStr Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
title_full_unstemmed Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
title_sort Implementation of oligonucleotide-gated supports for the electrochemical detection of Ochratoxin A
dc.creator.none.fl_str_mv Muthamizh, S.
Ribes, Àngela
Anusuyajanakiraman, M.
Narayanan, V.
Soto Camino, Juan
Martínez-Máñez, Ramón|||0000-0001-5873-9674
Aznar, Elena|||0000-0003-0361-3876
author Muthamizh, S.
author_facet Muthamizh, S.
Ribes, Àngela
Anusuyajanakiraman, M.
Narayanan, V.
Soto Camino, Juan
Martínez-Máñez, Ramón|||0000-0001-5873-9674
Aznar, Elena|||0000-0003-0361-3876
author_role author
author2 Ribes, Àngela
Anusuyajanakiraman, M.
Narayanan, V.
Soto Camino, Juan
Martínez-Máñez, Ramón|||0000-0001-5873-9674
Aznar, Elena|||0000-0003-0361-3876
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Química
Escuela Técnica Superior de Ingeniería Industrial
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico
Generalitat Valenciana
Ministerio de Economía, Industria y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Molecular gates
Mesoporous materials
Ochratoxin A
Sensing
Differential pulse voltammetry
Electron Microscopy Service of the UPV
QUIMICA INORGANICA
QUIMICA ANALITICA
topic Molecular gates
Mesoporous materials
Ochratoxin A
Sensing
Differential pulse voltammetry
Electron Microscopy Service of the UPV
QUIMICA INORGANICA
QUIMICA ANALITICA
description [EN] We report herein the design a hybrid material for the recognition of Ochratoxin A (OTA) by using an aptamer gated-material able to release electroactive species, which can be measured using differential pulse voltammetry. Mesoporous silica nanoparticles loaded with Methylene Blue and capped with an OTA aptamer were prepared and characterised. A highly selective and sensitive response due to the displacement of the capping aptamer in the presence of OTA and subsequent MB release was found in aqueous media. Finally, the possible use of the gated material for the detection of OTA in a real matrix was also explored.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/102309
url https://riunet.upv.es/handle/10251/102309
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2015-64139-C4-1-R NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO
Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEOII%2F2014%2F047 Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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