Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios
Organochlorine pesticides have been used in Mexico in agriculture, sanitation, malaria programs and livestock to combat ectoparasites. Due to their chemical stability, persistence and lipophility, their residues bioconcentrate in lipidrich tissues, according to the equilibrium pattern of internal tr...
| Autores: | , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | México |
| Institución: | UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO |
| Repositorio: | Revista Internacional de Contaminación Ambiental |
| Idioma: | español |
| OAI Identifier: | oai:ojs.pkp.sfu.ca:article/22550 |
| Acceso en línea: | https://www.revistascca.unam.mx/rica/index.php/rica/article/view/22550 |
| Access Level: | acceso abierto |
| Palabra clave: | pesticides breast tumors |
| id |
MX_fe16fd7810d21d02da4f8d7a0abb9dff |
|---|---|
| oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/22550 |
| network_acronym_str |
MX |
| network_name_str |
México |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios |
| title |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios |
| spellingShingle |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios WALISZEWSKI, Stefan M. pesticides breast tumors |
| title_short |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios |
| title_full |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios |
| title_fullStr |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios |
| title_full_unstemmed |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios |
| title_sort |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamarios |
| dc.creator.none.fl_str_mv |
WALISZEWSKI, Stefan M. BERMUDEZ, Marco T. SILVA, Carmen S. INFANZON, Rosa M. CARVAJAL, Octavio GÓMEZ ARROYO, Sandra VILLALOBOS PIETRINI, Rafael TRUJILLO, Patricia SALDAÑA, Vicente MELO, Guadalupe ESQUIVEL, Sergio CASTRO, Felipe OCAMPO, Héctor TORRES, J. HAYWARD-JONES, Patricia M. |
| author |
WALISZEWSKI, Stefan M. |
| author_facet |
WALISZEWSKI, Stefan M. BERMUDEZ, Marco T. SILVA, Carmen S. INFANZON, Rosa M. CARVAJAL, Octavio GÓMEZ ARROYO, Sandra VILLALOBOS PIETRINI, Rafael TRUJILLO, Patricia SALDAÑA, Vicente MELO, Guadalupe ESQUIVEL, Sergio CASTRO, Felipe OCAMPO, Héctor TORRES, J. HAYWARD-JONES, Patricia M. |
| author_role |
author |
| author2 |
BERMUDEZ, Marco T. SILVA, Carmen S. INFANZON, Rosa M. CARVAJAL, Octavio GÓMEZ ARROYO, Sandra VILLALOBOS PIETRINI, Rafael TRUJILLO, Patricia SALDAÑA, Vicente MELO, Guadalupe ESQUIVEL, Sergio CASTRO, Felipe OCAMPO, Héctor TORRES, J. HAYWARD-JONES, Patricia M. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
pesticides breast tumors |
| topic |
pesticides breast tumors |
| description |
Organochlorine pesticides have been used in Mexico in agriculture, sanitation, malaria programs and livestock to combat ectoparasites. Due to their chemical stability, persistence and lipophility, their residues bioconcentrate in lipidrich tissues, according to the equilibrium pattern of internal transport and lipid tissue content. The studies on their role as estrogenic or antiandrogenic agents have related these pesticides to breast cancer. Therefore, organochlorine pesticides were determined in breast adipose tissue of women subjected to surgery due to the diagnosis of breast abnormalities. The study pool constituted 127 women with malignant breast tumors, 127 with benign breast tumors and 127 in a control group without breast abnormalities. The pesticides determined were: HCB, β-HCH, pp’DDE, op’DDT, pp’DDT and Σ-DDT. Comparing the studied groups, the highest residue levels were determined in the benign breast tumor group. The determined levels from the control group through malignant to benign cases increased stepwise; HCB: 0.045, 0.099, 0.116 mg kg-1 ,β-HCH: 0.163, 0.265, 0.319 mg kg-1 , pp’DDE: 0.782, 0.980, 1.761 mg kg-1 , op’DDT: 0.035, 0.094, 0.176 mg kg-1 , pp’DDT: 0.296, 0.351, 0.661 mg kg-1 ,SDDT: 1.112, 1.423, 2.601 mg kg-1 , respectively. Paired analyses of the three groups revealed divergences among them and correlation of these pesticide levels with breast tumors. Calculated relative risk (RR) values for the benign to control group and the malignant to control cases presented the following values: HCB: 2.11, 2.01, β-HCH: 1.96, 1.58, pp’DDE: 2.13, 1.17, op’DDT: 4.42, 2.27, pp’DDT: 2.33, 1.33, Σ-DDT: 2.21, 1.19 respectively. The obtained results indicate higher organochlorine pesticide residue levels in women with benign breast abnormalities and higher relative risk related to op’DDT presence. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010-12-13 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ART |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://www.revistascca.unam.mx/rica/index.php/rica/article/view/22550 |
| url |
https://www.revistascca.unam.mx/rica/index.php/rica/article/view/22550 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://www.revistascca.unam.mx/rica/index.php/rica/article/view/22550/21674 |
| dc.rights.none.fl_str_mv |
Derechos de autor 2017 Revista Internacional de Contaminación Ambiental info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Derechos de autor 2017 Revista Internacional de Contaminación Ambiental |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Instituto de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México |
| publisher.none.fl_str_mv |
Instituto de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México |
| dc.source.none.fl_str_mv |
Revista Internacional de Contaminación Ambiental; Vol. 21 Núm. 3 (2005); 133-142 Revista Internacional de Contaminación Ambiental; Vol. 21 No. 3 (2005); 133-142 0188-4999 reponame:Revista Internacional de Contaminación Ambiental instname:UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO instacron:UNAM |
| instname_str |
UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO |
| instacron_str |
UNAM |
| institution |
UNAM |
| reponame_str |
Revista Internacional de Contaminación Ambiental |
| collection |
Revista Internacional de Contaminación Ambiental |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1858177823830704128 |
| spelling |
Niveles de DDT, HCH y HCB en tejido adiposo de mujeres con tumores mamariosWALISZEWSKI, Stefan M.BERMUDEZ, Marco T.SILVA, Carmen S.INFANZON, Rosa M.CARVAJAL, OctavioGÓMEZ ARROYO, SandraVILLALOBOS PIETRINI, RafaelTRUJILLO, PatriciaSALDAÑA, VicenteMELO, GuadalupeESQUIVEL, SergioCASTRO, FelipeOCAMPO, HéctorTORRES, J.HAYWARD-JONES, Patricia M.pesticidesbreast tumorsOrganochlorine pesticides have been used in Mexico in agriculture, sanitation, malaria programs and livestock to combat ectoparasites. Due to their chemical stability, persistence and lipophility, their residues bioconcentrate in lipidrich tissues, according to the equilibrium pattern of internal transport and lipid tissue content. The studies on their role as estrogenic or antiandrogenic agents have related these pesticides to breast cancer. Therefore, organochlorine pesticides were determined in breast adipose tissue of women subjected to surgery due to the diagnosis of breast abnormalities. The study pool constituted 127 women with malignant breast tumors, 127 with benign breast tumors and 127 in a control group without breast abnormalities. The pesticides determined were: HCB, β-HCH, pp’DDE, op’DDT, pp’DDT and Σ-DDT. Comparing the studied groups, the highest residue levels were determined in the benign breast tumor group. The determined levels from the control group through malignant to benign cases increased stepwise; HCB: 0.045, 0.099, 0.116 mg kg-1 ,β-HCH: 0.163, 0.265, 0.319 mg kg-1 , pp’DDE: 0.782, 0.980, 1.761 mg kg-1 , op’DDT: 0.035, 0.094, 0.176 mg kg-1 , pp’DDT: 0.296, 0.351, 0.661 mg kg-1 ,SDDT: 1.112, 1.423, 2.601 mg kg-1 , respectively. Paired analyses of the three groups revealed divergences among them and correlation of these pesticide levels with breast tumors. Calculated relative risk (RR) values for the benign to control group and the malignant to control cases presented the following values: HCB: 2.11, 2.01, β-HCH: 1.96, 1.58, pp’DDE: 2.13, 1.17, op’DDT: 4.42, 2.27, pp’DDT: 2.33, 1.33, Σ-DDT: 2.21, 1.19 respectively. The obtained results indicate higher organochlorine pesticide residue levels in women with benign breast abnormalities and higher relative risk related to op’DDT presence.En México, los plaguicidas organoclorados se ha utilizado en agricultura, salud pública en programas del combate a la malaria y a ectoparásitos de ganado. Debido a su estabilidad química, persistencia y lipofilidad, sus residuos se biomagnifican en tejidos ricos en grasa de acuerdo con el estado de equilibrio entre el transporte interno y el contenido de lípidos en tejidos. Los estudios sobre su papel como agentes estrogénicos o antiandrogénicos relacionan a los plaguicidas organoclorados con el cáncer mamario. Por esta razón se determinaron los niveles de plaguicidas organoclorados en mujeres sujetas a cirugía para diagnosticar anomalías mamarias. En el estudio participaron 127 pacientes con tumor maligno de seno, 127 pacientes con tumor benigno de seno y 127 pacientes como testigos sin anomalías mamarias. Los plaguicidas estudiados fueron: HCB, β-HCH, pp’DDE, op’DDT, pp’DDT y Σ-DDT. Comparando con el grupo testigo, el nivel superior se determinó en las pacientes con tumor benigno de mama. Los niveles de plaguicidas organoclorados desde el grupo testigo al grupo de casos malignos y benignos se incrementó paulatinamente: HCB: 0.045, 0.099, 0.116 mg kg-1 , β-HCH: 0.163, 0.265, 0.319 mg kg-1 , pp’DDE: 0.782, 0.980, 1.761 mg kg-1 , op’DDT: 0.035, 0.094, 0.176 mg kg-1 , pp’DDT: 0.296, 0.351, 0.661 mg kg-1 , Σ-DDT: 1.112, 1.423, 2.601 mg kg-1 , respectivamente. El análisis pareado de medias reveló divergencia entre los tres grupos y correlación de los niveles de plaguicidas organoclorados en el tumor mamario benigno. Al calcular los valores del riesgo relativo (RR) para los grupos con tumor mamario benigno y maligno, se obtuvieron los valores siguientes: HCB: 2.11, 2.01, bHCH: 1.96, 1.58, pp’DDE: 2.13, 1.17, op’DDT: 4.42, 2.27, pp’DDT: 2.33, 1.33, Σ-DDT: 2.21, 1.19, respectivamente. Los resultados obtenidos indican mayores concentraciones de plaguicidas organoclorados en mujeres con anomalías benignas de seno y un riesgo relativo mayor relacionado con la presencia del op’DDT.Instituto de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México2010-12-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionARTapplication/pdfhttps://www.revistascca.unam.mx/rica/index.php/rica/article/view/22550Revista Internacional de Contaminación Ambiental; Vol. 21 Núm. 3 (2005); 133-142Revista Internacional de Contaminación Ambiental; Vol. 21 No. 3 (2005); 133-1420188-4999reponame:Revista Internacional de Contaminación Ambientalinstname:UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICOinstacron:UNAMspahttps://www.revistascca.unam.mx/rica/index.php/rica/article/view/22550/21674Derechos de autor 2017 Revista Internacional de Contaminación Ambientalinfo:eu-repo/semantics/openAccessoai:ojs.pkp.sfu.ca:article/225502024-08-16T19:00:28Z |
| score |
15,81155 |