DDT¿S, HCH AND HCB LEVELS IN BREAST ADIPOSE TISSUE IN WOMEN WITH BREAST TUMORS
Organochlorine pesticides have been used in Mexico in agriculture, sanitation, malariaprograms and livestock to combat ectoparasites. Due to their chemical stability, persistenceand lipophility, their residues bioconcentrate in lipidrichtissues, according to theequilibrium pattern of internal transp...
| Autores: | , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | México |
| Recursos: | Universidad Veracruzana |
| Repositorio: | Redalyc-UV |
| OAI Identifier: | oai:redalyc.org:37021304 |
| Acesso em linha: | https://www.redalyc.org/articulo.oa?id=37021304 |
| Access Level: | acceso abierto |
| Palavra-chave: | Ciencias de la Tierra pesticides breast tumors |
| Resumo: | Organochlorine pesticides have been used in Mexico in agriculture, sanitation, malariaprograms and livestock to combat ectoparasites. Due to their chemical stability, persistenceand lipophility, their residues bioconcentrate in lipidrichtissues, according to theequilibrium pattern of internal transport and lipid tissue content. The studies on their roleas estrogenic or antiandrogenic agents have related these pesticides to breast cancer.Therefore, organochlorine pesticides were determined in breast adipose tissue of womensubjected to surgery due to the diagnosis of breast abnormalities. The study pool constituted127 women with malignant breast tumors, 127 with benign breast tumors and 127 ina control group without breast abnormalities. The pesticides determined were: HCB, bHCH,ppDDE, opDDT, ppDDT andSDDT.Comparing the studied groups, the highestresidue levels were determined in the benign breast tumor group. The determined levelsfrom the control group through malignant to benign cases increased stepwise; HCB:0.045, 0.099, 0.116 mg kg 1,bHCH:0.163, 0.265, 0.319 mg kg 1, ppDDE: 0.782, 0.980, 1.761mg kg 1, opDDT: 0.035, 0.094, 0.176 mg kg 1, ppDDT: 0.296, 0.351, 0.661 mg kg 1,SDDT:1.112, 1.423, 2.601 mg kg 1, respectively. Paired analyses of the three groups revealeddivergences among them and correlation of these pesticide levels with breast tumors.Calculated relative risk (RR) values for the benign to control group and the malignant tocontrol cases presented the following values: HCB: 2.11, 2.01, bHCH:1.96, 1.58, ppDDE:2.13, 1.17, opDDT: 4.42, 2.27, ppDDT: 2.33, 1.33, SDDT:2.21, 1.19 respectively. Theobtained results indicate higher organochlorine pesticide residue levels in women withbenign breast abnormalities and higher relative risk related to opDDT presence. |
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