Serotonina y noradrenalina en el hipocampo dorsal de ratas estresadas prenatalmente y su relación con el aprendizaje y la memoria espacial: participación de la corticosterona
Prenatal stress causes spatial learning and memory deficits at any stage of postnatal life by modifying hippocampal function. Serotonergic and noradrenergic axon terminals, involved in cognitive processes, are present the hippocampus. Despite studies about the participation of both neurochemical sys...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | México |
| Institución: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:k3569448p |
| Acceso en línea: | https://doi.org/10.24275/uami.k3569448p |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/LEM/Episodic memory info:eu-repo/classification/LEM/Fetus Diseases info:eu-repo/classification/LEM/Biología experimental info:eu-repo/classification/LEM/Learning disabilities info:eu-repo/classification/LEM/Memoria episódica info:eu-repo/classification/LEM/Hippocampus (Brain) info:eu-repo/classification/LEM/Feto -- Enfermedades info:eu-repo/classification/LEM/Trastornos del aprendizaje info:eu-repo/classification/LEM/Hipocampo (Cerebro) info:eu-repo/classification/cti/2 |
| Sumario: | Prenatal stress causes spatial learning and memory deficits at any stage of postnatal life by modifying hippocampal function. Serotonergic and noradrenergic axon terminals, involved in cognitive processes, are present the hippocampus. Despite studies about the participation of both neurochemical systems in cognitive processes, it is currently unknown whether prenatal stress affects the release of serotonin (5-HT) and noradrenaline (NA) in the dorsal hippocampus during cognitive performance. Therefore, the aim of this work was to evaluate 5-HT and NA changes in the dorsal hippocampus during spatial learning and memory in prenatally stressed rats. Spatial learning and memory tests were performed using the Morris Water Maze (MWM) in 3- month-old, control and prenatally stressed males. Dorsal hippocampus was dissected in basal conditions, and after learning and memory to quantify 5-HT and NA content. Trunk blood samples were also obtained for corticosterone evaluation. Stereotaxic surgeries were performed in other males to perform microdialysis and evaluate the extracellular concentration of 5-HT and NA in the dorsal hippocampus, both at baseline and after behavioral tests. In the Morris water maze higher arrival latencies were observed in prenatally stressed animals along the training days, as well as a shorter time and fewer crosses in the quadrant compared with control animals during the memory trial. 5-HT content decreased during learning and memory tasks in both groups, but NA content was lower in the prenatal stress group during behavioral tests. 5-HT and NA release in dorsal hippocampus was significantly lower in prenatally stressed animals during behavioral tests. Serotonin transporter basal content was higher in prenatally stressed animals, but no changes were observed during behavioral tests. The adrenal axis response was higher in prenatally stressed animals than in controls. Taking together, the results of this work show that cognitive impairment caused by prenatal stress is related to decreased 5-HT and NA release, as well as to the high levels of corticosterone. Serotonin transporter seems not to be involved in learning and memory disruption caused by prenatal stress. |
|---|