Alteraciones reproductivas en ratas macho y hembra estresadas prenatalmente, conducta sexual, ciclo estral y calidad espermática
Stress isa physiologicalreactionofthebodywhich allows coping witha situation thatis perceived as threatening.The intensity and durationof the stressorare important determinantsin the responseof theorganism, so that prolonged exposureto a stressormay result insomepathology. Theintrauterine environmen...
| Autor: | |
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | México |
| Institución: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:jw827b79w |
| Acceso en línea: | https://doi.org/10.24275/uami.jw827b79w |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/LEM/Oxidative stress info:eu-repo/classification/LEM/Sexual behavior in animals info:eu-repo/classification/LEM/Estrés oxidativo info:eu-repo/classification/LEM/Rats -- Reproduction info:eu-repo/classification/LEM/Ratas info:eu-repo/classification/LEM/Conducta sexual en los animales info:eu-repo/classification/LEM/Generative organs -- Diseases info:eu-repo/classification/LEM/Organos reproductores info:eu-repo/classification/cti/6 |
| Sumario: | Stress isa physiologicalreactionofthebodywhich allows coping witha situation thatis perceived as threatening.The intensity and durationof the stressorare important determinantsin the responseof theorganism, so that prolonged exposureto a stressormay result insomepathology. Theintrauterine environmenton fetusmayalsoinfluence susceptibilityto neurological, metabolic or endocrine diseasesin adulthood. Prenatalstresshas been linked toearlyprogramming ofbrain function,because it causespermanent changesonsome reproductivepatternsof offspringin adulthood, so moreinformation isrequired.Therefore,the aim of thisstudy was to evaluatethe effects of prenatal stress on some reproductiveparametersin males and females and its consequences in fertility.PregnantWistarratswere usedand assigned to one of two groups: Control (CON) andprenatalstress (PS). TheCON groupremainedundisturbed.TheEPgroup underwentstressby immersionin cold waterfrom day16 to 21of gestation, twice daily. After birth the litterswerehomogenized; they were sexed and weanedat22days. At three monthsofage,reproductive parametersmentionedassessmentbegan.Female offspringshowed higher corticosterone levels than control;the percentage of PS femaleswithabnormalestrous cycleswas higherthan in control females, as well as higher estradiol levels in Proestrus and Estrus.Lordoticquotient in PS femaleswas similarto thecontrolgroup, but the intensity of lordosis wasmlower. Ovarianweightin proestrusstagewas lower in PS group.Regarding males, The percentage of ejaculating males was lower in PS; mountand intromissionlatencieswere higher thanin controlsTesticularweightand testosterone levels were lower inPS males.The number of apoptotic Leydig and germinal cells, as well as percentage of apoptotic cell per tubule were higher in PS males. Sperm viability, motility and countwere lower thanin controls. Likewise, corticosterone levels were higher in PS males compared withcontrol males.Fertilityrate in both PS males and females was lower than in the control groups. Finally, PSfemales had fewer pups per litter. The results of this work show that prenatal stress disruptsseveralreproductive patternsin offspring, probably by exposing them to high levels of maternal glucocorticoids, leading to a decreasedfertility, bothin malesand femalesin adulthood. |
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