Efectos de la estimulación táctil sobre la neurogénesis hipocampal, el aprendizaje espacial y la memoria en ratas estresadas prenatalmente
Neurogenesis in the dentate gyrus (DG) of the hippocampus is increased by spatial learning and postnatal stimulation. Conversely, prenatal stress (PS) produces a decrease in the proliferation of hippocampal granular cells. This work evaluated the effect of postnatal tactile stimulation (PTS), when a...
| Autor: | |
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | México |
| Institución: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:1544bp60n |
| Acceso en línea: | https://doi.org/10.24275/uami.1544bp60n |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/LEM/Stress (Physiology) info:eu-repo/classification/LEM/Estrés (Fisiología) info:eu-repo/classification/LEM/Hippocampus (Brain) info:eu-repo/classification/LEM/Hipocampo (Cerebro) info:eu-repo/classification/cti/2 |
| Sumario: | Neurogenesis in the dentate gyrus (DG) of the hippocampus is increased by spatial learning and postnatal stimulation. Conversely, prenatal stress (PS) produces a decrease in the proliferation of hippocampal granular cells. This work evaluated the effect of postnatal tactile stimulation (PTS), when applied from birth to adulthood (3 months old), on cognitive performance and hippocampal neurogenesis (survival and differentiation) in both genders prenatally stressed. Also we evaluated the adrenal response after the animals performed the Morris water maze test (MWM)) was also analyzed. PS by immersion in cold water was provided the last third of gestation (days 15 through 21). Hippocampal neurogenesis and cognitive performance in the MWM were assessed in rats of three months of age. Results showed that escape latencies of both female and male PS rats were longer when they were compared with the control group (CON). DG cell survival increased in the PS female rats. Corticosterone (CORT) concentrations were significantly higher in the male and female PS rats after MWM training. PTS decrease escape latencies and increased the number of new neurons in the DG of PS animals. CORT concentrations were similar to those in CON. In CON, PTS diminished DG cell survival but increased differentiation to neurons and reduced latency in the MWM. These results show that long-term PTS in PS animals might prevent learning deficits in adults through increase in the number of DG new neurons and decrease of the reactivity of the adrenal axis to MWM training. |
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