Multiple Halogenation of Aliphatic C-H Bonds within the Hofmann- Löffler Manifold
An innovative approach to position-selective polyhalogenation of aliphatic hydrocarbon bonds is presented. The reaction proceeds within the Hofmann-Löffler manifold with amidyl radicals as the sole mediators to induce selective 1,5- and 1,6- hydrogen atom transfer followed by halogenation. Multiple...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/356014 |
| Acceso en línea: | http://hdl.handle.net/2072/356014 https://doi.org/10.1002/chem.201804504 |
| Access Level: | acceso abierto |
| Palabra clave: | 54 |
| Sumario: | An innovative approach to position-selective polyhalogenation of aliphatic hydrocarbon bonds is presented. The reaction proceeds within the Hofmann-Löffler manifold with amidyl radicals as the sole mediators to induce selective 1,5- and 1,6- hydrogen atom transfer followed by halogenation. Multiple halogenation events of up to four innate C-H bond functionalizations have been accomplished. The broad applicability of this new entry into polyhalogenation and the resulting synthetic possibilities are demonstrated for a total of 27 different examples including mixed halogenations. |
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