Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk
Atherosclerosis is considered a low-grade inflammatory disease. Polyphenol-rich alcoholic beverages (red wine) have shown a more pronounced antiinflammatory effect than polyphenol-free alcoholic beverages (gin). However, no studies to our knowledge have evaluated the antiinflammatory effects of alco...
| Autores: | , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2007 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/59012 |
| Acesso em linha: | https://hdl.handle.net/2445/59012 |
| Access Level: | acceso embargado |
| Palavra-chave: | Aterosclerosi Cava Malalties cardiovasculars Factors de risc en les malalties Inflamació Homes Polifenols Alcohol Atherosclerosis Cava (Sparkling wine) Cardiovascular diseases Risk factors in diseases Inflammation Men Polyphenols |
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Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular riskVàzquez Agell, MònicaSacanella Meseguer, EmilioTobías, EsterMonagas, MariaAntúnez Jorge, EmiliaZamora-Ros, RaulAndrés Lacueva, Ma. CristinaLamuela Raventós, Rosa Ma.Fernández-Solà, J. (Joaquim)Nicolás Arfelis, Josep MariaEstruch Riba, RamonAterosclerosiCavaMalalties cardiovascularsFactors de risc en les malaltiesInflamacióHomesPolifenolsAlcoholAtherosclerosisCava (Sparkling wine)Cardiovascular diseasesRisk factors in diseasesInflammationMenPolyphenolsAlcoholAtherosclerosis is considered a low-grade inflammatory disease. Polyphenol-rich alcoholic beverages (red wine) have shown a more pronounced antiinflammatory effect than polyphenol-free alcoholic beverages (gin). However, no studies to our knowledge have evaluated the antiinflammatory effects of alcoholic beverages with medium-level polyphenol content such as cava (sparkling wine). We enrolled 20 healthy men (aged 34 6 9 y) in a randomized crossover study to receive 30 g ethanol/d as cava or gin for 28 d. Before both interventions, subjects abstained from alcohol for 2 wk. Inflammatory biomarkers of atherosclerosis and expression of adhesion molecules on peripheral leukocytes were measured before and after each intervention. Likewise, dietary intake and exercise were also evaluated. Expression of lymphocyte function associated antigen-1 (LFA-1), very late activation antigen-4 (VLA-4), Sialyl-Lewisx (SLex), and CD40 on monocytes decreased after cava intake (all P , 0.05), whereas only SLex was reduced after gin intake (P ¼ 0.036). Circulating markers of atherosclerosis including vascular cell adhesion molecule-1, E-selectin, and P-selectin decreased after both interventions (all P , 0.05). High-sensitivity C-reactive protein, intercellular adhesion molecule-1 (ICAM-1), IL-6, monocyte hemoattractant protein-1 (MCP-1), and CD40L were diminished only after cava intake (all P , 0.05). The effects of cava on circulating CD40L, ICAM-1, and MCP-1, and monocyte surface expression of CD40, LFA-1, and VLA-4 were greater than those of gin (all P , 0.05). In conclusion, both cava and gin showed antiinflammatory properties; however, cava had a greater protective effect, probably due its polyphenol content.American Society for Nutrition2007info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/59012Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléshttp://jn.nutrition.org/content/137/10/2279.longJournal of Nutrition, 2007, vol. 137, num. 10, p. 2279-2284(c) American Society for Nutrition, 2007info:eu-repo/semantics/embargoedAccessoai:diposit.ub.edu:2445/590122026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk |
| title |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk |
| spellingShingle |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk Vàzquez Agell, Mònica Aterosclerosi Cava Malalties cardiovasculars Factors de risc en les malalties Inflamació Homes Polifenols Alcohol Atherosclerosis Cava (Sparkling wine) Cardiovascular diseases Risk factors in diseases Inflammation Men Polyphenols Alcohol |
| title_short |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk |
| title_full |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk |
| title_fullStr |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk |
| title_full_unstemmed |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk |
| title_sort |
Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk |
| dc.creator.none.fl_str_mv |
Vàzquez Agell, Mònica Sacanella Meseguer, Emilio Tobías, Ester Monagas, Maria Antúnez Jorge, Emilia Zamora-Ros, Raul Andrés Lacueva, Ma. Cristina Lamuela Raventós, Rosa Ma. Fernández-Solà, J. (Joaquim) Nicolás Arfelis, Josep Maria Estruch Riba, Ramon |
| author |
Vàzquez Agell, Mònica |
| author_facet |
Vàzquez Agell, Mònica Sacanella Meseguer, Emilio Tobías, Ester Monagas, Maria Antúnez Jorge, Emilia Zamora-Ros, Raul Andrés Lacueva, Ma. Cristina Lamuela Raventós, Rosa Ma. Fernández-Solà, J. (Joaquim) Nicolás Arfelis, Josep Maria Estruch Riba, Ramon |
| author_role |
author |
| author2 |
Sacanella Meseguer, Emilio Tobías, Ester Monagas, Maria Antúnez Jorge, Emilia Zamora-Ros, Raul Andrés Lacueva, Ma. Cristina Lamuela Raventós, Rosa Ma. Fernández-Solà, J. (Joaquim) Nicolás Arfelis, Josep Maria Estruch Riba, Ramon |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Aterosclerosi Cava Malalties cardiovasculars Factors de risc en les malalties Inflamació Homes Polifenols Alcohol Atherosclerosis Cava (Sparkling wine) Cardiovascular diseases Risk factors in diseases Inflammation Men Polyphenols Alcohol |
| topic |
Aterosclerosi Cava Malalties cardiovasculars Factors de risc en les malalties Inflamació Homes Polifenols Alcohol Atherosclerosis Cava (Sparkling wine) Cardiovascular diseases Risk factors in diseases Inflammation Men Polyphenols Alcohol |
| description |
Atherosclerosis is considered a low-grade inflammatory disease. Polyphenol-rich alcoholic beverages (red wine) have shown a more pronounced antiinflammatory effect than polyphenol-free alcoholic beverages (gin). However, no studies to our knowledge have evaluated the antiinflammatory effects of alcoholic beverages with medium-level polyphenol content such as cava (sparkling wine). We enrolled 20 healthy men (aged 34 6 9 y) in a randomized crossover study to receive 30 g ethanol/d as cava or gin for 28 d. Before both interventions, subjects abstained from alcohol for 2 wk. Inflammatory biomarkers of atherosclerosis and expression of adhesion molecules on peripheral leukocytes were measured before and after each intervention. Likewise, dietary intake and exercise were also evaluated. Expression of lymphocyte function associated antigen-1 (LFA-1), very late activation antigen-4 (VLA-4), Sialyl-Lewisx (SLex), and CD40 on monocytes decreased after cava intake (all P , 0.05), whereas only SLex was reduced after gin intake (P ¼ 0.036). Circulating markers of atherosclerosis including vascular cell adhesion molecule-1, E-selectin, and P-selectin decreased after both interventions (all P , 0.05). High-sensitivity C-reactive protein, intercellular adhesion molecule-1 (ICAM-1), IL-6, monocyte hemoattractant protein-1 (MCP-1), and CD40L were diminished only after cava intake (all P , 0.05). The effects of cava on circulating CD40L, ICAM-1, and MCP-1, and monocyte surface expression of CD40, LFA-1, and VLA-4 were greater than those of gin (all P , 0.05). In conclusion, both cava and gin showed antiinflammatory properties; however, cava had a greater protective effect, probably due its polyphenol content. |
| publishDate |
2007 |
| dc.date.none.fl_str_mv |
2007 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/59012 |
| url |
https://hdl.handle.net/2445/59012 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
http://jn.nutrition.org/content/137/10/2279.long Journal of Nutrition, 2007, vol. 137, num. 10, p. 2279-2284 |
| dc.rights.none.fl_str_mv |
(c) American Society for Nutrition, 2007 info:eu-repo/semantics/embargoedAccess |
| rights_invalid_str_mv |
(c) American Society for Nutrition, 2007 |
| eu_rights_str_mv |
embargoedAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
American Society for Nutrition |
| publisher.none.fl_str_mv |
American Society for Nutrition |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15.300719 |