Conservation of CavA, CavB and Vfr across the A. baumannii pangenome [Dataset]
A—Heatmap of the protein profile of CavA, CavB and Vfr in the A. baumannii pangenome. The genomes are clustered (rows) by the variants of the proteins they present. The most frequent variant of the protein (ref) is depicted in orange and the other variants are shown in different shades of purple. Th...
| Autores: | , , , , |
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| Tipo de recurso: | conjunto de datos |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/373266 |
| Acceso en línea: | http://hdl.handle.net/10261/373266 |
| Access Level: | acceso abierto |
| Palabra clave: | Throughput screening approach Modulating quorum sensing Current treatment options Baumannii &# 8217 Ultimately governing virulence Adaptive antibiotic resistance Opportunistic nosocomial pathogen High potential target Acinetobacter baumannii </ Ac ), cava Baumannii </ Virulence regulation Increasing resistance Cava ac Vivo </ Various aspects Using drna Study uncovers Signalling cascade Second messengers Resort antibiotics Pathogenic success Mortality rates Leading position Inversely regulated Intrabacterial signalling High morbidity Gmp systems First time Exopolysaccharide production Established paradigm Directly proportional Cyclic di Cyclic amp gy Crucial mediator Central regulator Bacterial physiology |
| Sumario: | A—Heatmap of the protein profile of CavA, CavB and Vfr in the A. baumannii pangenome. The genomes are clustered (rows) by the variants of the proteins they present. The most frequent variant of the protein (ref) is depicted in orange and the other variants are shown in different shades of purple. The left side of the heatmap shows the metadata: Multilocus sequence typing (MLST) (the 5 most frequent, highlighting ST2), and host source (predominantly human but also hospital environment, environment and other). Highlighted are A. baumannii strains commonly used as reference: ATCC17978 (GCF_902728005.1), ATCC19606 (GCF_014116795.1), ACICU (GCF_000018445.1), AYE (GCF_000069245.1), AB5075 (GCF_000770605.1), AB0057 (GCF_000021245.2). B—Proportion of different sequence variants (v) of CavA, CavB and Vfr proteins in the A. baumannii pangenome. The vref variant represents the most frequent, and "not found" appears when the protein has not been found. The number of genomes per group is as follows: Human (6589), Hospital environment (131), Environmental (140), Other (2836). |
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