Inflammatory mediators and dual depression
Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and treatment response. Recent studies reported alterati...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:223567 |
| Acceso en línea: | https://ddd.uab.cat/record/223567 https://dx.doi.org/urn:doi:10.1371/journal.pone.0213791 |
| Access Level: | acceso abierto |
| Palabra clave: | Adult Alcoholism Biomarkers Case-Control Studies Cocaine-Related Disorders Depressive Disorder, Major Female Humans Inflammation Mediators Male Middle Aged Prevalence Spain Substance-Related Disorders |
| id |
ES_d4a336988693e182e8ea1a34e33caab1 |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:223567 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Inflammatory mediators and dual depression Potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders |
| title |
Inflammatory mediators and dual depression |
| spellingShingle |
Inflammatory mediators and dual depression García Marchena, Nuria|||0000-0002-0575-3613 Adult Alcoholism Biomarkers Case-Control Studies Cocaine-Related Disorders Depressive Disorder, Major Female Humans Inflammation Mediators Male Middle Aged Prevalence Spain Substance-Related Disorders |
| title_short |
Inflammatory mediators and dual depression |
| title_full |
Inflammatory mediators and dual depression |
| title_fullStr |
Inflammatory mediators and dual depression |
| title_full_unstemmed |
Inflammatory mediators and dual depression |
| title_sort |
Inflammatory mediators and dual depression |
| dc.creator.none.fl_str_mv |
García Marchena, Nuria|||0000-0002-0575-3613 Barrera-Conde, Marta|||0000-0002-0106-0000 Mestre-Pintó, Joan-Ignasi|||0000-0003-0387-9375 Araos, Pedro|||0000-0001-5172-8796 Serrano, Antonia Pérez-Mañá, Clara|||0000-0001-6343-6918 Papaseit, Esther|||0000-0003-2620-4274 Fonseca, Francina|||0000-0002-0779-6545 Ruiz, Juan Jesús Rodríguez de Fonseca, Fernando|||0000-0002-4516-5795 Farré Albaladejo, Magí|||0000-0001-8338-7543 Pavón, Francisco Javier Torrens, Marta |
| author |
García Marchena, Nuria|||0000-0002-0575-3613 |
| author_facet |
García Marchena, Nuria|||0000-0002-0575-3613 Barrera-Conde, Marta|||0000-0002-0106-0000 Mestre-Pintó, Joan-Ignasi|||0000-0003-0387-9375 Araos, Pedro|||0000-0001-5172-8796 Serrano, Antonia Pérez-Mañá, Clara|||0000-0001-6343-6918 Papaseit, Esther|||0000-0003-2620-4274 Fonseca, Francina|||0000-0002-0779-6545 Ruiz, Juan Jesús Rodríguez de Fonseca, Fernando|||0000-0002-4516-5795 Farré Albaladejo, Magí|||0000-0001-8338-7543 Pavón, Francisco Javier Torrens, Marta |
| author_role |
author |
| author2 |
Barrera-Conde, Marta|||0000-0002-0106-0000 Mestre-Pintó, Joan-Ignasi|||0000-0003-0387-9375 Araos, Pedro|||0000-0001-5172-8796 Serrano, Antonia Pérez-Mañá, Clara|||0000-0001-6343-6918 Papaseit, Esther|||0000-0003-2620-4274 Fonseca, Francina|||0000-0002-0779-6545 Ruiz, Juan Jesús Rodríguez de Fonseca, Fernando|||0000-0002-4516-5795 Farré Albaladejo, Magí|||0000-0001-8338-7543 Pavón, Francisco Javier Torrens, Marta |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Adult Alcoholism Biomarkers Case-Control Studies Cocaine-Related Disorders Depressive Disorder, Major Female Humans Inflammation Mediators Male Middle Aged Prevalence Spain Substance-Related Disorders |
| topic |
Adult Alcoholism Biomarkers Case-Control Studies Cocaine-Related Disorders Depressive Disorder, Major Female Humans Inflammation Mediators Male Middle Aged Prevalence Spain Substance-Related Disorders |
| description |
Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and treatment response. Recent studies reported alterations in the circulating expression of inflammatory mediators in patients with psychiatric disorders, including those related to substance use. The aim of the study was to explore TNF-α, IL-1β, CXCL12, CCL2, CCL11 (eotaxin-1) and CX3CL1 (fractalkine) as potential biomarkers to identify comorbid MDD and to distinguish primary MDD from substance-induced MDD in patients with substance disorders. Patients diagnosed with cocaine (CUD, n = 64) or alcohol (AUD, n = 65) use disorders with/without MDD were recruited from outpatient treatment programs [CUD/non-MDD (n = 31 CUD/primary MDD (n = 18 CUD/cocaine-induced MDD (N = 15 AUD/non-MDD (n = 27 AUD/primary MDD (n = 16) and AUD/alcohol-induced MDD (n = 22)]. Sixty-two healthy subjects were also recruited as control group. Substance and mental disorders were assessed according to "Diagnostic and Statistical Manual of Mental Disorders, 4 edition, text revision" (DSM-IV-TR) and a blood sample was collected for determinations in the plasma. The cocaine group showed lower TNF-α (p<0.05) and CCL11 (p<0.05), and higher IL-1β (p<0.01) concentrations than the control group. In contrast, the alcohol group showed higher IL-1β (p<0.01) and lower CXCL12 (p<0.01) concentrations than the control group. Regarding MDD, we only observed alterations in the cocaine group. Thus, CUD/MDD patients showed lower IL-1β (p<0.05), CXCL12 (p<0.05) and CCL11 (p<0.05), and higher CXC3CL1 (p<0.05) concentrations than CUD/non-MDD patients. Moreover, while CUD/primary MDD patients showed higher CCL11 (p<0.01) concentrations than both CUD/non-MDD and CUD/cocaine-induced MDD patients, CUD/cocaine-induced MDD patients showed lower CXCL12 (p<0.05) concentrations than CUD/non-MDD patients. Finally, a logistic regression model in the cocaine group identified CXCL12, CCL11 and sex to distinguish primary MDD from cocaine-induced MDD providing a high discriminatory power. The present data suggest an association between changes in inflammatory mediators and the diagnosis of primary and substance-induced MDD, namely in CUD patients. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2 2019-01-01 2019 2019-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/223567 https://dx.doi.org/urn:doi:10.1371/journal.pone.0213791 |
| url |
https://ddd.uab.cat/record/223567 https://dx.doi.org/urn:doi:10.1371/journal.pone.0213791 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12-0028-0021 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12-0028-0009 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0017-0001 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0017-0010 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0017-003 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09-02121 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12-01838 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-01698 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-01953 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP14-00173 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP14-00212 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-316 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-530 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869420564366491648 |
| spelling |
Inflammatory mediators and dual depressionPotential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disordersGarcía Marchena, Nuria|||0000-0002-0575-3613Barrera-Conde, Marta|||0000-0002-0106-0000Mestre-Pintó, Joan-Ignasi|||0000-0003-0387-9375Araos, Pedro|||0000-0001-5172-8796Serrano, AntoniaPérez-Mañá, Clara|||0000-0001-6343-6918Papaseit, Esther|||0000-0003-2620-4274Fonseca, Francina|||0000-0002-0779-6545Ruiz, Juan JesúsRodríguez de Fonseca, Fernando|||0000-0002-4516-5795Farré Albaladejo, Magí|||0000-0001-8338-7543Pavón, Francisco JavierTorrens, MartaAdultAlcoholismBiomarkersCase-Control StudiesCocaine-Related DisordersDepressive Disorder, MajorFemaleHumansInflammation MediatorsMaleMiddle AgedPrevalenceSpainSubstance-Related DisordersMajor depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and treatment response. Recent studies reported alterations in the circulating expression of inflammatory mediators in patients with psychiatric disorders, including those related to substance use. The aim of the study was to explore TNF-α, IL-1β, CXCL12, CCL2, CCL11 (eotaxin-1) and CX3CL1 (fractalkine) as potential biomarkers to identify comorbid MDD and to distinguish primary MDD from substance-induced MDD in patients with substance disorders. Patients diagnosed with cocaine (CUD, n = 64) or alcohol (AUD, n = 65) use disorders with/without MDD were recruited from outpatient treatment programs [CUD/non-MDD (n = 31 CUD/primary MDD (n = 18 CUD/cocaine-induced MDD (N = 15 AUD/non-MDD (n = 27 AUD/primary MDD (n = 16) and AUD/alcohol-induced MDD (n = 22)]. Sixty-two healthy subjects were also recruited as control group. Substance and mental disorders were assessed according to "Diagnostic and Statistical Manual of Mental Disorders, 4 edition, text revision" (DSM-IV-TR) and a blood sample was collected for determinations in the plasma. The cocaine group showed lower TNF-α (p<0.05) and CCL11 (p<0.05), and higher IL-1β (p<0.01) concentrations than the control group. In contrast, the alcohol group showed higher IL-1β (p<0.01) and lower CXCL12 (p<0.01) concentrations than the control group. Regarding MDD, we only observed alterations in the cocaine group. Thus, CUD/MDD patients showed lower IL-1β (p<0.05), CXCL12 (p<0.05) and CCL11 (p<0.05), and higher CXC3CL1 (p<0.05) concentrations than CUD/non-MDD patients. Moreover, while CUD/primary MDD patients showed higher CCL11 (p<0.01) concentrations than both CUD/non-MDD and CUD/cocaine-induced MDD patients, CUD/cocaine-induced MDD patients showed lower CXCL12 (p<0.05) concentrations than CUD/non-MDD patients. Finally, a logistic regression model in the cocaine group identified CXCL12, CCL11 and sex to distinguish primary MDD from cocaine-induced MDD providing a high discriminatory power. The present data suggest an association between changes in inflammatory mediators and the diagnosis of primary and substance-induced MDD, namely in CUD patients. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/223567https://dx.doi.org/urn:doi:10.1371/journal.pone.0213791reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12-0028-0021Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12-0028-0009Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0017-0001Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0017-0010Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0017-003Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09-02121Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12-01838Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-01698Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-01953Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP14-00173Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP14-00212Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-316Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-530open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2235672026-06-06T12:50:31Z |
| score |
15.298079 |