Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder.

Granulocyte colony-stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we i...

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Detalles Bibliográficos
Autores: Galván, Sandra Torres, Flores-López, María, Romero-Sanchiz, Pablo, Requena-Ocaña, Nerea, Porras-Perales, Oscar, Nogueira-Arjona, Raquel, Mayoral, Fermín, Araos, Pedro, Serrano, Antonia, Muga, Roberto, Pavón, Francisco Javier, García-Marchena, Nuria, de Fonseca, Fernando Rodríguez
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18393
Acceso en línea:http://hdl.handle.net/20.500.12105/18393
Access Level:acceso abierto
Palabra clave:Adult
Alcoholism
Cocaine-Related Disorders
Comorbidity
Depressive Disorder, Major
Diagnosis, Dual (Psychiatry)
Female
Granulocyte Colony-Stimulating Factor
Humans
Male
Middle Aged
Substance-Related Disorders
Descripción
Sumario:Granulocyte colony-stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = - 0.233, p 

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