Inflammatory mediators and dual depression: Potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders.

Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and treatment response. Recent studies reported alterati...

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Detalles Bibliográficos
Autores: García-Marchena, Nuria, Barrera, Marta, Mestre-Pintó, Joan Ignasi, Araos, Pedro, Serrano, Antonia, Pérez-Mañá, Clara, Papaseit, Esther, Fonseca, Francina, Ruiz, Juan Jesús, Rodríguez de Fonseca, Fernando, Farré, Magí, Pavón, Francisco Javier, Torrens, Marta
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17831
Acceso en línea:http://hdl.handle.net/20.500.12105/17831
Access Level:acceso abierto
Palabra clave:Adult
Alcoholism
Biomarkers
Case-Control Studies
Cocaine-Related Disorders
Depressive Disorder, Major
Female
Humans
Inflammation Mediators
Male
Middle Aged
Prevalence
Spain
Substance-Related Disorders
Descripción
Sumario:Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and treatment response. Recent studies reported alterations in the circulating expression of inflammatory mediators in patients with psychiatric disorders, including those related to substance use. The aim of the study was to explore TNF-α, IL-1β, CXCL12, CCL2, CCL11 (eotaxin-1) and CX3CL1 (fractalkine) as potential biomarkers to identify comorbid MDD and to distinguish primary MDD from substance-induced MDD in patients with substance disorders. Patients diagnosed with cocaine (CUD, n = 64) or alcohol (AUD, n = 65) use disorders with/without MDD were recruited from outpatient treatment programs [CUD/non-MDD (n = 31); CUD/primary MDD (n = 18); CUD/cocaine-induced MDD (N = 15); AUD/non-MDD (n = 27); AUD/primary MDD (n = 16) and AUD/alcohol-induced MDD (n = 22)]. Sixty-two healthy subjects were also recruited as control group. Substance and mental disorders were assessed according to "Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision" (DSM-IV-TR) and a blood sample was collected for determinations in the plasma. The cocaine group showed lower TNF-α (p

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