New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent

Though curcumin has been demonstrated as highly cytotoxic towards various cancer cell lines, the major drawbacks for its use are the insolubility and instability in water to provoke low bioavailability. On the other hand, carbosilane dendritic systems with cationic charge on the surface have been st...

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Autores: Ortega Lopez, Paula|||0000-0003-0377-5429, Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935, Gómez Ramírez, Rafael|||0000-0001-6448-2414, Lozano de la Cruz, Tania
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/35920
Acceso en línea:http://hdl.handle.net/10017/35920
https://dx.doi.org/10.1039/c8nj01713a
Access Level:acceso abierto
Palabra clave:curcumin
dendrimers
carbosilane, MCF-7
Antioxidant, antitumoral
Química
Chemistry
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spelling New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agentOrtega Lopez, Paula|||0000-0003-0377-5429Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935Gómez Ramírez, Rafael|||0000-0001-6448-2414Lozano de la Cruz, Taniacurcumindendrimerscarbosilane, MCF-7Antioxidant, antitumoralQuímicaChemistryThough curcumin has been demonstrated as highly cytotoxic towards various cancer cell lines, the major drawbacks for its use are the insolubility and instability in water to provoke low bioavailability. On the other hand, carbosilane dendritic systems with cationic charge on the surface have been studied in different biomedical applications such as antibacterial, anticancer or as non-viral vehicles for the delivery of nucleic acids. In this study, we combine both systems by synthesizing a new "bow-tie" cationic carbosilane dendrimer where curcumin is located at the core. The resulting new system is completely water-soluble, conserves the antioxidant properties and induces higher cytotoxicity against MCF-7 cancer cells than free curcumin. In addition, the effects on the cell cycle and apoptosis induction by using flow cytometry analysis are evaluated to obtain insights of the cytotoxic mechanism of action.20182018-01-0120182018-01-0120192019-08-31journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/35920https://dx.doi.org/10.1039/c8nj01713areponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/359202026-06-18T11:13:07Z
dc.title.none.fl_str_mv New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
title New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
spellingShingle New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
Ortega Lopez, Paula|||0000-0003-0377-5429
curcumin
dendrimers
carbosilane, MCF-7
Antioxidant, antitumoral
Química
Chemistry
title_short New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
title_full New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
title_fullStr New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
title_full_unstemmed New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
title_sort New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
dc.creator.none.fl_str_mv Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Gómez Ramírez, Rafael|||0000-0001-6448-2414
Lozano de la Cruz, Tania
author Ortega Lopez, Paula|||0000-0003-0377-5429
author_facet Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Gómez Ramírez, Rafael|||0000-0001-6448-2414
Lozano de la Cruz, Tania
author_role author
author2 Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Gómez Ramírez, Rafael|||0000-0001-6448-2414
Lozano de la Cruz, Tania
author2_role author
author
author
dc.subject.none.fl_str_mv curcumin
dendrimers
carbosilane, MCF-7
Antioxidant, antitumoral
Química
Chemistry
topic curcumin
dendrimers
carbosilane, MCF-7
Antioxidant, antitumoral
Química
Chemistry
description Though curcumin has been demonstrated as highly cytotoxic towards various cancer cell lines, the major drawbacks for its use are the insolubility and instability in water to provoke low bioavailability. On the other hand, carbosilane dendritic systems with cationic charge on the surface have been studied in different biomedical applications such as antibacterial, anticancer or as non-viral vehicles for the delivery of nucleic acids. In this study, we combine both systems by synthesizing a new "bow-tie" cationic carbosilane dendrimer where curcumin is located at the core. The resulting new system is completely water-soluble, conserves the antioxidant properties and induces higher cytotoxicity against MCF-7 cancer cells than free curcumin. In addition, the effects on the cell cycle and apoptosis induction by using flow cytometry analysis are evaluated to obtain insights of the cytotoxic mechanism of action.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
2019
2019-08-31
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/35920
https://dx.doi.org/10.1039/c8nj01713a
url http://hdl.handle.net/10017/35920
https://dx.doi.org/10.1039/c8nj01713a
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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