Supercritical sage extracts as anti-inflammatory food ingredients
The anti-inflammatory capacity of supercritical CO2 extracts (S1 and S2) obtained from sage (Salvia officinalis) was evaluated using THP-1 human macrophages activated with human ox-LDL, a specific in vitro model to determine the anti-inflammatory effect of the extracts in an atherosclerotic environm...
| Authors: | , , , , , |
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| Format: | article |
| Status: | Versión enviada para evaluación y publicación |
| Publication Date: | 2014 |
| Country: | España |
| Institution: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repository: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/383995 |
| Online Access: | http://hdl.handle.net/10261/383995 |
| Access Level: | Open access |
| Keyword: | Sage Anti-atherogenic model Anti-inflammatory activity Anti-inflammatory cytokines Supercritical extracts |
| Summary: | The anti-inflammatory capacity of supercritical CO2 extracts (S1 and S2) obtained from sage (Salvia officinalis) was evaluated using THP-1 human macrophages activated with human ox-LDL, a specific in vitro model to determine the anti-inflammatory effect of the extracts in an atherosclerotic environment. The expression of pro-inflammatory cytokines, with an important role in the atherogenic process, such as TNF-α, IL-1β and IL-6, in presence of different extracts concentrations was evaluated. Results showed that 30 μg/mL of both supercritical extracts (S1 and S2) markedly suppressed the ox-LDL induced production of TNF-α, IL-1β and IL-6, as well as their mRNA expression. Data showed that S1 presented a higher anti-inflammatory activity than S2. |
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