Generation of a human iPSC line from a patient with Leigh syndrome

Human iPSC line LND554SV.3 was generated from heteroplasmic fibroblasts of a patient with Leigh syndrome carrying a mutation in the MT-ND5 gene (m.13513G. >. A; p.D393N). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the us...

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Detalles Bibliográficos
Autores: Galera, Teresa, Zurita, Francisco, González-Páramo, Cristina, Moreno-Izquierdo, Ana, Fraga, Mario F., Fernández, Agustín F., Garesse Alarcón, Rafael, Gallardo, M. Esther
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:español
OAI Identifier:oai:repositorio.uam.es:10486/677841
Acceso en línea:http://hdl.handle.net/10486/677841
https://dx.doi.org/10.1016/j.scr.2015.12.005
Access Level:acceso abierto
Palabra clave:Induced pluripotent stem cells
IPS cells
IPSC
Leigh syndrome
MT-ND5
Medicina
Descripción
Sumario:Human iPSC line LND554SV.3 was generated from heteroplasmic fibroblasts of a patient with Leigh syndrome carrying a mutation in the MT-ND5 gene (m.13513G. >. A; p.D393N). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.

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