Generation of a human control iPSC line with a European mitochondrial haplogroup U background

Human iPSC line N44SV.5 was generated from primary normal human dermal fibroblasts belonging to the European mitochondrial haplogroup U. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.

Detalhes bibliográficos
Autores: Galera, Teresa, Zurita, Francisco, González-Páramos, Cristina, Moreno-Izquierdo, Ana, Fraga, Mario F., Fernández, Agustín F., Garesse Alarcón, Rafael, Gallardo, M. Esther
Formato: artículo
Fecha de publicación:2016
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/677840
Acesso em linha:http://hdl.handle.net/10486/677840
https://dx.doi.org/10.1016/j.scr.2015.12.010
Access Level:acceso abierto
Palavra-chave:Defects of intergenomic communication
Induced pluripotent stem cells
IPS cells
IPSC
POLG
Medicina
Descrição
Resumo:Human iPSC line N44SV.5 was generated from primary normal human dermal fibroblasts belonging to the European mitochondrial haplogroup U. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.

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