Generation of a human control iPSC line with a European mitochondrial haplogroup U background

Human iPSC line N44SV.5 was generated from primary normal human dermal fibroblasts belonging to the European mitochondrial haplogroup U. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.

Detalhes bibliográficos
Autores: Galera, Teresa, Zurita Díaz, Francisco, González Páramos, Cristina, Moreno-Izquierdo, Ana, Fraga, Mario F., Fernández, Agustín F., Garesse, Rafael, Gallardo, M. Esther
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/173210
Acesso em linha:http://hdl.handle.net/10261/173210
Access Level:acceso abierto
Palavra-chave:POLG
iPS cells
Induced pluripotent stem cells
Defects of intergenomic communication
iPSC
Descrição
Resumo:Human iPSC line N44SV.5 was generated from primary normal human dermal fibroblasts belonging to the European mitochondrial haplogroup U. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.

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