Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol

The in vitro anti-inflammatory activity of supercritical rosemary (Rosmarinus officinalis L.) extracts (rosemary A and B) is been reported in this study. To achieve that, THP-1 macrophages were activated using lipopolysaccharide or human ox-LDL and secretion and gene expression of TNF-α, IL-1β, IL-6...

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Autores: Arranz, Elena, Jaime, Laura, García-Risco, Mónica R., Fornari, Tiziana, Reglero, Guillermo, Santoyo, Susana
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/113757
Acceso en línea:http://hdl.handle.net/10261/113757
Access Level:acceso abierto
Palabra clave:Anti-inflammatory activity
Carnosic acid
Rosemary
Supercritical extracts
Anti-atherogenic activity
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spelling Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosolArranz, ElenaJaime, LauraGarcía-Risco, Mónica R.Fornari, TizianaReglero, GuillermoSantoyo, SusanaAnti-inflammatory activityCarnosic acidRosemarySupercritical extractsAnti-atherogenic activityThe in vitro anti-inflammatory activity of supercritical rosemary (Rosmarinus officinalis L.) extracts (rosemary A and B) is been reported in this study. To achieve that, THP-1 macrophages were activated using lipopolysaccharide or human ox-LDL and secretion and gene expression of TNF-α, IL-1β, IL-6 and IL-10 were evaluated, as well as COX-2 gene expression. Results indicated that both rosemary extracts (A & B) exhibit high anti-inflammatory activity although at a higher extent in case of rosemary B extract (5 μg mL-1), representing a higher quantity of carnosic acid and carnosol than rosemary A. When comparing the activity of the extract to the standard itself, the anti-inflammatory activity of standards of carnosic acid and carnosol was not as intense as that obtained with rosemary B. These data indicated that although carnosic acid content in the extracts is considered as the main anti-inflammatory compound, a synergistic interaction with other compounds may play a significant role in enhancing its activity. Results provided the grounds for possible increase in the application of supercritical rosemary extracts in food formulations for mitigation or prevention of inflammatory diseases. In this study the in vitro anti-inflammatory activity of supercritical rosemary (Rosmarinus officinalis L.) extracts is been reported. Results provided the grounds for increasing the applicability of supercritical rosemary extracts in formulations for the prevention of inflammatory diseases.Financial support from Spanish Ministry of Science and Innovation (CICYT) (Project: IPT-300000-2010-034) Ingredientes Saludables Mediterráneos Innovadores (INNSAMED) and Comunidad Autónoma de Madrid (ALIBIRD, project S-505/AGR-0153).Peer reviewedPeer ReviewedJohn Wiley & SonsMinisterio de Ciencia e Innovación (España)Comunidad de MadridComisión Interministerial de Ciencia y Tecnología, CICYT (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2015201520152015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionapplication/pdfhttp://hdl.handle.net/10261/113757reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInglés#PLACEHOLDER_PARENT_METADATA_VALUE#S2013/ABI-2728/ALIBIRD-CMSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1137572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
title Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
spellingShingle Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
Arranz, Elena
Anti-inflammatory activity
Carnosic acid
Rosemary
Supercritical extracts
Anti-atherogenic activity
title_short Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
title_full Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
title_fullStr Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
title_full_unstemmed Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
title_sort Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
dc.creator.none.fl_str_mv Arranz, Elena
Jaime, Laura
García-Risco, Mónica R.
Fornari, Tiziana
Reglero, Guillermo
Santoyo, Susana
author Arranz, Elena
author_facet Arranz, Elena
Jaime, Laura
García-Risco, Mónica R.
Fornari, Tiziana
Reglero, Guillermo
Santoyo, Susana
author_role author
author2 Jaime, Laura
García-Risco, Mónica R.
Fornari, Tiziana
Reglero, Guillermo
Santoyo, Susana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Comunidad de Madrid
Comisión Interministerial de Ciencia y Tecnología, CICYT (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Anti-inflammatory activity
Carnosic acid
Rosemary
Supercritical extracts
Anti-atherogenic activity
topic Anti-inflammatory activity
Carnosic acid
Rosemary
Supercritical extracts
Anti-atherogenic activity
description The in vitro anti-inflammatory activity of supercritical rosemary (Rosmarinus officinalis L.) extracts (rosemary A and B) is been reported in this study. To achieve that, THP-1 macrophages were activated using lipopolysaccharide or human ox-LDL and secretion and gene expression of TNF-α, IL-1β, IL-6 and IL-10 were evaluated, as well as COX-2 gene expression. Results indicated that both rosemary extracts (A & B) exhibit high anti-inflammatory activity although at a higher extent in case of rosemary B extract (5 μg mL-1), representing a higher quantity of carnosic acid and carnosol than rosemary A. When comparing the activity of the extract to the standard itself, the anti-inflammatory activity of standards of carnosic acid and carnosol was not as intense as that obtained with rosemary B. These data indicated that although carnosic acid content in the extracts is considered as the main anti-inflammatory compound, a synergistic interaction with other compounds may play a significant role in enhancing its activity. Results provided the grounds for possible increase in the application of supercritical rosemary extracts in food formulations for mitigation or prevention of inflammatory diseases. In this study the in vitro anti-inflammatory activity of supercritical rosemary (Rosmarinus officinalis L.) extracts is been reported. Results provided the grounds for increasing the applicability of supercritical rosemary extracts in formulations for the prevention of inflammatory diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/113757
url http://hdl.handle.net/10261/113757
dc.language.none.fl_str_mv Inglés
Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
S2013/ABI-2728/ALIBIRD-CM
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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