Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis

Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics incl...

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Detalles Bibliográficos
Autores: López Cuenca, Inés, García Martín, Elena Salobrar, Gil Salgado, Inés, Sánchez-Puebla Fernández, Lidia, Elvira Hurtado, Lorena, Fernández Albarral, José, Ramírez Toraño, Federico, Barabash Bustelo, Ana, De Frutos Lucas, Jaisalmer, Salazar Corral, Juan José, Ramírez Sebastián, José Manuel, Ramírez Sebastián, Ana Isabel, Hoz Montañana, María Rosa De
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/71694
Acceso en línea:https://hdl.handle.net/20.500.14352/71694
Access Level:acceso abierto
Palabra clave:616.894-053.9
611.843.112:616.894-053.9
611.843.112:616-073.75
Alzheimer’s disease
ApoE ɛ4
Family history
Hard drusen
OCT
Retina
AMD
Hypercholesterolemia
Hypertension
Diabetes mellitus
Choroid
Neurociencias (Medicina)
Oftalmología
Anatomía ocular
Técnicas de la imagen
2490 Neurociencias
3201.09 Oftalmología
Descripción
Sumario:Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH- or FH+) and their allelic characterization of ApoE ɛ4 (ApoE ɛ4- or ApoE ɛ4+) and considering cardiovascular risk factors (hypercholesterolemia, hypertension, and diabetes mellitus). In addition, we analyzed the choroidal thickness by OCT and the area of the foveal avascular zone with OCTA. We did not find a relationship between a family history of AD or any of the ApoE isoforms and the presence or absence of drusen. Subjects with drusen show choroidal thinning compared to patients without drusen, and thinning could trigger changes in choroidal perfusion that may give rise to the deposits that generate drusen

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