Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease

A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroi...

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Detalles Bibliográficos
Autores: López Cuenca, Inés, Hoz Montañana, María Rosa De, Alcántara Rey, Celia, García Martín, Elena Salobrar, Elvira Hurtado, Lorena, Fernández Albarral, José, Barabash Bustelo, Ana, Ramírez Toraño, Federico, De Frutos Lucas, Jaisalmer, Salazar Corral, Juan José, Ramírez Sebastián, Ana Isabel, Ramírez Sebastián, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8353
Acceso en línea:https://hdl.handle.net/20.500.14352/8353
Access Level:acceso abierto
Palabra clave:617.736
617.723
617.735
616.894-053.9
Alzheimer’s
Family history
ApoE ε4
AMD
Choroid
Foveal avascular zone
Hard drusen
Retina
OCT
OCTA
Neurociencias (Medicina)
Oftalmología
2490 Neurociencias
3201.09 Oftalmología
Descripción
Sumario:A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ε4−, HD+) group compared with (i) both the (FH−, ε4−, HD−) and the (FH+, ε4+, HD+) groups in the superior and inferior points at 1500 µm, and (ii) the (FH+, ε4−, HD+) group in the superior point at 1500 µm. There were statistically significant differences in the superficial FAZ between the (FH+, ε4−, HD+) group and (i) the (FH+, ε4−, HD−) group and (ii) the (FH+, ε4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD.

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