Macular Thickness as a Potential Biomarker of Mild Alzheimer's Disease

Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fiber layer (RNFL) may be the earliest sign of AD, e...

ver descrição completa

Detalhes bibliográficos
Autores: García Martín, Elena Salobrar, Rojas López, María Blanca, Ramírez Sebastián, Ana Isabel, Hoz Montañana, María Rosa De, Salazar Corral, Juan José, Yubero Pancorbo, Raquel, Gil Gregorio, Pedro, Triviño Casado, Alberto, Ramírez Sebastián, José Manuel
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/35304
Acesso em linha:https://hdl.handle.net/20.500.14352/35304
Access Level:acceso abierto
Palavra-chave:616.894-053.9
617.736
Macular thickness
Biomarkers
Alzheimer's disease
Neurociencias (Medicina)
Oftalmología
Anatomía ocular
2490 Neurociencias
3201.09 Oftalmología
Descrição
Resumo:Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fiber layer (RNFL) may be the earliest sign of AD, even before damage to the hippocampal region that affects memory. This fact may reflect retinal neuronal-ganglion cell death and axonal loss in the optic nerve in addition to aging.

Registos relacionados