Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry.
AIMS To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. METHODS AND RESULTS Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/16855 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/16855 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 Cardiomyopathy, Hypertrophic Ventricular Dysfunction, Left Atrial Fibrillation Humans Male Adult Middle Aged Aged Female SARS-CoV-2 Registries |
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Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry.Gimeno, Juan ROlivotto, IacopoRodríguez, Ana IsabelHo, Carolyn YFernández, AdriánQuiroga, AlejandroEspinosa, Mari AngelesGómez-González, CristinaRobledo, MaríaTojal-Sierra, LucasDay, Sharlene MOwens, AnjaliBarriales-Villa, RobertoLarrañaga, Jose MaríaRodríguez-Palomares, JoseGonzález-Del-Hoyo, MaribelPiqueras-Flores, JesúsReza, NosheenChumakova, OlgaAshley, Euan AParikh, VictoriaWheeler, MatthewJacoby, DanielPereira, Alexandre CSaberi, SaraHelms, Adam SVillacorta, EduardoGallego-Delgado, Maríade Castro, DanielDomínguez, FernandoRipoll-Vera, TomásZorio-Grima, EstherSánchez-Martínez, José CarlosGarcía-Álvarez, AnaArbelo, ElenaMogollón, María VictoriaFuentes-Cañamero, María EugeniaGrande, EliasPeña, CarlosMonserrat, LorenzoLakdawala, Neal KCOVID-19Cardiomyopathy, HypertrophicVentricular Dysfunction, LeftAtrial FibrillationHumansMaleAdultMiddle AgedAgedFemaleSARS-CoV-2RegistriesAIMS To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. METHODS AND RESULTS Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12-4.51], P = 0.0229}, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75-9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16-26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20-49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98-2.91, P = 0.0600). CONCLUSIONS Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality.Wiley20232023-12-2020222022-08-0120222022-08-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/16855reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/168552026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. |
| title |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. |
| spellingShingle |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. Gimeno, Juan R COVID-19 Cardiomyopathy, Hypertrophic Ventricular Dysfunction, Left Atrial Fibrillation Humans Male Adult Middle Aged Aged Female SARS-CoV-2 Registries |
| title_short |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. |
| title_full |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. |
| title_fullStr |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. |
| title_full_unstemmed |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. |
| title_sort |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. |
| dc.creator.none.fl_str_mv |
Gimeno, Juan R Olivotto, Iacopo Rodríguez, Ana Isabel Ho, Carolyn Y Fernández, Adrián Quiroga, Alejandro Espinosa, Mari Angeles Gómez-González, Cristina Robledo, María Tojal-Sierra, Lucas Day, Sharlene M Owens, Anjali Barriales-Villa, Roberto Larrañaga, Jose María Rodríguez-Palomares, Jose González-Del-Hoyo, Maribel Piqueras-Flores, Jesús Reza, Nosheen Chumakova, Olga Ashley, Euan A Parikh, Victoria Wheeler, Matthew Jacoby, Daniel Pereira, Alexandre C Saberi, Sara Helms, Adam S Villacorta, Eduardo Gallego-Delgado, María de Castro, Daniel Domínguez, Fernando Ripoll-Vera, Tomás Zorio-Grima, Esther Sánchez-Martínez, José Carlos García-Álvarez, Ana Arbelo, Elena Mogollón, María Victoria Fuentes-Cañamero, María Eugenia Grande, Elias Peña, Carlos Monserrat, Lorenzo Lakdawala, Neal K |
| author |
Gimeno, Juan R |
| author_facet |
Gimeno, Juan R Olivotto, Iacopo Rodríguez, Ana Isabel Ho, Carolyn Y Fernández, Adrián Quiroga, Alejandro Espinosa, Mari Angeles Gómez-González, Cristina Robledo, María Tojal-Sierra, Lucas Day, Sharlene M Owens, Anjali Barriales-Villa, Roberto Larrañaga, Jose María Rodríguez-Palomares, Jose González-Del-Hoyo, Maribel Piqueras-Flores, Jesús Reza, Nosheen Chumakova, Olga Ashley, Euan A Parikh, Victoria Wheeler, Matthew Jacoby, Daniel Pereira, Alexandre C Saberi, Sara Helms, Adam S Villacorta, Eduardo Gallego-Delgado, María de Castro, Daniel Domínguez, Fernando Ripoll-Vera, Tomás Zorio-Grima, Esther Sánchez-Martínez, José Carlos García-Álvarez, Ana Arbelo, Elena Mogollón, María Victoria Fuentes-Cañamero, María Eugenia Grande, Elias Peña, Carlos Monserrat, Lorenzo Lakdawala, Neal K |
| author_role |
author |
| author2 |
Olivotto, Iacopo Rodríguez, Ana Isabel Ho, Carolyn Y Fernández, Adrián Quiroga, Alejandro Espinosa, Mari Angeles Gómez-González, Cristina Robledo, María Tojal-Sierra, Lucas Day, Sharlene M Owens, Anjali Barriales-Villa, Roberto Larrañaga, Jose María Rodríguez-Palomares, Jose González-Del-Hoyo, Maribel Piqueras-Flores, Jesús Reza, Nosheen Chumakova, Olga Ashley, Euan A Parikh, Victoria Wheeler, Matthew Jacoby, Daniel Pereira, Alexandre C Saberi, Sara Helms, Adam S Villacorta, Eduardo Gallego-Delgado, María de Castro, Daniel Domínguez, Fernando Ripoll-Vera, Tomás Zorio-Grima, Esther Sánchez-Martínez, José Carlos García-Álvarez, Ana Arbelo, Elena Mogollón, María Victoria Fuentes-Cañamero, María Eugenia Grande, Elias Peña, Carlos Monserrat, Lorenzo Lakdawala, Neal K |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
COVID-19 Cardiomyopathy, Hypertrophic Ventricular Dysfunction, Left Atrial Fibrillation Humans Male Adult Middle Aged Aged Female SARS-CoV-2 Registries |
| topic |
COVID-19 Cardiomyopathy, Hypertrophic Ventricular Dysfunction, Left Atrial Fibrillation Humans Male Adult Middle Aged Aged Female SARS-CoV-2 Registries |
| description |
AIMS To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. METHODS AND RESULTS Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12-4.51], P = 0.0229}, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75-9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16-26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20-49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98-2.91, P = 0.0600). CONCLUSIONS Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-08-01 2022 2022-08-01 2023 2023-12-20 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12105/16855 |
| url |
http://hdl.handle.net/20.500.12105/16855 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-sa/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-sa/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
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reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Repisalud |
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Repisalud |
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1869411063505616896 |
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15,812429 |