Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry.

AIMS To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. METHODS AND RESULTS Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with...

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Autores: Gimeno, Juan R, Olivotto, Iacopo, Rodríguez, Ana Isabel, Ho, Carolyn Y, Fernández, Adrián, Quiroga, Alejandro, Espinosa, Mari Angeles, Gómez-González, Cristina, Robledo, María, Tojal-Sierra, Lucas, Day, Sharlene M, Owens, Anjali, Barriales-Villa, Roberto, Larrañaga, Jose María, Rodríguez-Palomares, Jose, González-Del-Hoyo, Maribel, Piqueras-Flores, Jesús, Reza, Nosheen, Chumakova, Olga, Ashley, Euan A, Parikh, Victoria, Wheeler, Matthew, Jacoby, Daniel, Pereira, Alexandre C, Saberi, Sara, Helms, Adam S, Villacorta, Eduardo, Gallego-Delgado, María, de Castro, Daniel, Domínguez, Fernando, Ripoll-Vera, Tomás, Zorio-Grima, Esther, Sánchez-Martínez, José Carlos, García-Álvarez, Ana, Arbelo, Elena, Mogollón, María Victoria, Fuentes-Cañamero, María Eugenia, Grande, Elias, Peña, Carlos, Monserrat, Lorenzo, Lakdawala, Neal K
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/16855
Acceso en línea:http://hdl.handle.net/20.500.12105/16855
Access Level:acceso abierto
Palabra clave:COVID-19
Cardiomyopathy, Hypertrophic
Ventricular Dysfunction, Left
Atrial Fibrillation
Humans
Male
Adult
Middle Aged
Aged
Female
SARS-CoV-2
Registries
Descripción
Sumario:AIMS To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. METHODS AND RESULTS Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12-4.51], P = 0.0229}, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75-9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16-26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20-49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98-2.91, P = 0.0600). CONCLUSIONS Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality.

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