Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy

To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infect...

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Autores: Gimeno-Blanes, Juan R.|||0000-0001-5818-1754, Olivotto, Iacopo|||0000-0003-1751-9266, Rodríguez, Ana Isabel, Ho, Carolyn Y., Fernández, Adrián, Quiroga, Alejandro, Espinosa, Maria Angeles, Gómez-González, Cristina, Robledo, María, Tojal-Sierra, Lucas|||0000-0001-5338-9601, Day, Sharlene M., Owens, Anjali, Barriales-Villa, Roberto|||0000-0002-6721-3487, Larrañaga, Jose María, Rodríguez Palomares, José F.|||0000-0002-7229-9780, González-del-Hoyo, Maribel|||0000-0003-0587-050X, Piqueras-Flores, Jesús, Reza, Nosheen, Chumakova, Olga, Ashley, Euan A., Parikh, Victoria, Wheeler, Matthew, Jacoby, Daniel, Pereira, Alexandre C., Saberi, Sara, Helms, Adam S., Villacorta, Eduardo|||0000-0003-0486-1740, Gallego-Delgado, María|||0000-0003-0726-9646, de Castro, Daniel, Domınguez, Fernando|||0000-0001-8408-363X, Ripoll-Vera, Tomás|||0000-0001-9222-325X, Zorio, Esther|||0000-0003-3608-4210, Sánchez-Martínez, José Carlos, García-Álvarez, Ana|||0000-0002-1718-2424, Arbelo, Elena|||0000-0003-0424-6393, Mogollón, María Victoria, Fuentes-Cañamero, María Eugenia, Grande, Elias, Peña, Carlos, Monserrat, Lorenzo|||0000-0001-5776-0623, Lakdawala, Neal K.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:282989
Acceso en línea:https://ddd.uab.cat/record/282989
https://dx.doi.org/urn:doi:10.1002/ehf2.13964
Access Level:acceso abierto
Palabra clave:COVID-19
Heart failure
Hypertrophic cardiomyopathy
Prognosis
Registry
SARS-CoV-2 infection
Descripción
Sumario:To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12-4.51], P = 0.0229}, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75-9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16-26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20-49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98-2.91, P = 0.0600). Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality.

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