Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial

The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study in...

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Autores: Sánchez-Rodriguez, Estefanía, Lima-Cabello, Elena, Biel-Glesson, Sara, Fernández-Navarro, Jose-Ramón, Calleja, Miguel Angel, Roca Bigorra, Maria, Espejo-Calvo, Juan A., Gil-Extremera, Blas, Soria-Florido, Maria, Torre Fornell, Rafael de la, Fitó Colomer, Montserrat, Covas Planells, Maria Isabel, Alche, Juan de Dios, Martínez de Victoria, Emilio, Gil, Angel, Mesa, Maria-Dolores
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/35741
Acceso en línea:http://hdl.handle.net/10230/35741
http://dx.doi.org/10.3390/nu10050626
Access Level:acceso abierto
Palabra clave:Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
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spelling Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trialSánchez-Rodriguez, EstefaníaLima-Cabello, ElenaBiel-Glesson, SaraFernández-Navarro, Jose-RamónCalleja, Miguel AngelRoca Bigorra, MariaEspejo-Calvo, Juan A.Gil-Extremera, BlasSoria-Florido, MariaTorre Fornell, Rafael de laFitó Colomer, MontserratCovas Planells, Maria IsabelAlche, Juan de DiosMartínez de Victoria, EmilioGil, AngelMesa, Maria-DoloresOlive oilVirgin olive oilOlive oil polyphenolsMaslinic acidOleanolic acidCardiovascular diseasesEndothelial functionPhenolic compoundsTriterpenesMetabolic syndromeThe aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).MDPI201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35741http://dx.doi.org/10.3390/nu10050626reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNutrients. 2018;10(5):e626© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/357412026-06-12T07:21:37Z
dc.title.none.fl_str_mv Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
title Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
spellingShingle Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
Sánchez-Rodriguez, Estefanía
Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
title_short Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
title_full Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
title_fullStr Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
title_full_unstemmed Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
title_sort Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
dc.creator.none.fl_str_mv Sánchez-Rodriguez, Estefanía
Lima-Cabello, Elena
Biel-Glesson, Sara
Fernández-Navarro, Jose-Ramón
Calleja, Miguel Angel
Roca Bigorra, Maria
Espejo-Calvo, Juan A.
Gil-Extremera, Blas
Soria-Florido, Maria
Torre Fornell, Rafael de la
Fitó Colomer, Montserrat
Covas Planells, Maria Isabel
Alche, Juan de Dios
Martínez de Victoria, Emilio
Gil, Angel
Mesa, Maria-Dolores
author Sánchez-Rodriguez, Estefanía
author_facet Sánchez-Rodriguez, Estefanía
Lima-Cabello, Elena
Biel-Glesson, Sara
Fernández-Navarro, Jose-Ramón
Calleja, Miguel Angel
Roca Bigorra, Maria
Espejo-Calvo, Juan A.
Gil-Extremera, Blas
Soria-Florido, Maria
Torre Fornell, Rafael de la
Fitó Colomer, Montserrat
Covas Planells, Maria Isabel
Alche, Juan de Dios
Martínez de Victoria, Emilio
Gil, Angel
Mesa, Maria-Dolores
author_role author
author2 Lima-Cabello, Elena
Biel-Glesson, Sara
Fernández-Navarro, Jose-Ramón
Calleja, Miguel Angel
Roca Bigorra, Maria
Espejo-Calvo, Juan A.
Gil-Extremera, Blas
Soria-Florido, Maria
Torre Fornell, Rafael de la
Fitó Colomer, Montserrat
Covas Planells, Maria Isabel
Alche, Juan de Dios
Martínez de Victoria, Emilio
Gil, Angel
Mesa, Maria-Dolores
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
topic Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
description The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35741
http://dx.doi.org/10.3390/nu10050626
url http://hdl.handle.net/10230/35741
http://dx.doi.org/10.3390/nu10050626
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nutrients. 2018;10(5):e626
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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