Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical t...

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Bibliographic Details
Authors: Pastick, Katelyn A., Okafor, Elizabeth C., Wang, Fan, Lofgren, Sarah M., Skipper, Caleb P., Nicol, Melanie R., Pullen, Matthew F., Rajasingham, Radha, McDonald, Emily G, Lee, Todd C., Schwartz, Ilan S., Kelly, Lauren E., Lother, Sylvain A., Mitjà Villar, Oriol, Letang, Emilio, Abassi, Mahsa, Boulware, David R.
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173948
Online Access:https://hdl.handle.net/2445/173948
Access Level:Open access
Keyword:SARS-CoV-2
Parasitologia mèdica
Medical parasitology
Description
Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. While there is a growing body of scientific data, there is also concern for harm, particularly QTc prolongation and cardiac arrhythmias. Here, we perform a rapid narrative review and discuss the strengths and limitations of existing in vitro and clinical studies. We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines.

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