Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment

Gatifloxacin (GAT), a fluoroquinolone, does not present a monograph described in official compendia and the literature presents some analytical methods for its evaluation, but with space for eco-efficient methods. The objective was to develop and validate a green and indicative of stability method b...

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Autores: Teixeira, Max Well Silva, Gil, Eric de Souza, Kogawa, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Revista Drug Analytical Research
Idioma:inglés
OAI Identifier:oai:seer.ufrgs.br:article/134965
Acceso en línea:https://seer.ufrgs.br/index.php/dar/article/view/134965
Access Level:acceso abierto
Palabra clave:gatifloxacin
eye drops
spectrophotometry in ultraviolet region
green analytical chemistry
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spelling Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessmentgatifloxacineye dropsspectrophotometry in ultraviolet regiongreen analytical chemistryGatifloxacin (GAT), a fluoroquinolone, does not present a monograph described in official compendia and the literature presents some analytical methods for its evaluation, but with space for eco-efficient methods. The objective was to develop and validate a green and indicative of stability method by UV for quantitative evaluation of GAT in eye drops. Purified water, as a diluent, quartz cubette and 286 nm were used. The method was linear in the range of 4 – 12 µg mL-1 (0.9997), precise (RSD < 5 %), selective in the comparison of standard and sample and by the forced degradation, exact with average recovery of 100.21 %, robust against changes in wavelength, source of purified water and use of ultrasound. The method was able to quantify and evaluate the stability of GAT in eye drops in green form according to the Eco-Scale Assessment.Universidade Federal do Rio Grande do Sul2024-01-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufrgs.br/index.php/dar/article/view/13496510.22456/2527-2616.134965Drug Analytical Research; Vol. 7 No. 2 (2023); 3-8Drug Analytical Research; v. 7 n. 2 (2023); 3-82527-2616reponame:Revista Drug Analytical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/dar/article/view/134965/91173Pharmaceutical analysisCopyright (c) 2023 Drug Analytical Researchinfo:eu-repo/semantics/openAccessTeixeira, Max Well SilvaGil, Eric de SouzaKogawa, Ana2024-01-15T17:34:55Zoai:seer.ufrgs.br:article/134965Revistahttps://seer.ufrgs.br/index.php/dar/indexPUBhttps://seer.ufrgs.br/index.php/dar/oaidruganalyticalresearch@ufrgs.br2527-26162527-2616opendoar:2024-01-15T17:34:55Revista Drug Analytical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
title Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
spellingShingle Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
Teixeira, Max Well Silva
gatifloxacin
eye drops
spectrophotometry in ultraviolet region
green analytical chemistry
title_short Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
title_full Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
title_fullStr Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
title_full_unstemmed Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
title_sort Green method for quantification of gatifloxacin in eye drops using UV by eco-scale assessment
dc.creator.none.fl_str_mv Teixeira, Max Well Silva
Gil, Eric de Souza
Kogawa, Ana
author Teixeira, Max Well Silva
author_facet Teixeira, Max Well Silva
Gil, Eric de Souza
Kogawa, Ana
author_role author
author2 Gil, Eric de Souza
Kogawa, Ana
author2_role author
author
dc.subject.por.fl_str_mv gatifloxacin
eye drops
spectrophotometry in ultraviolet region
green analytical chemistry
topic gatifloxacin
eye drops
spectrophotometry in ultraviolet region
green analytical chemistry
description Gatifloxacin (GAT), a fluoroquinolone, does not present a monograph described in official compendia and the literature presents some analytical methods for its evaluation, but with space for eco-efficient methods. The objective was to develop and validate a green and indicative of stability method by UV for quantitative evaluation of GAT in eye drops. Purified water, as a diluent, quartz cubette and 286 nm were used. The method was linear in the range of 4 – 12 µg mL-1 (0.9997), precise (RSD < 5 %), selective in the comparison of standard and sample and by the forced degradation, exact with average recovery of 100.21 %, robust against changes in wavelength, source of purified water and use of ultrasound. The method was able to quantify and evaluate the stability of GAT in eye drops in green form according to the Eco-Scale Assessment.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/dar/article/view/134965
10.22456/2527-2616.134965
url https://seer.ufrgs.br/index.php/dar/article/view/134965
identifier_str_mv 10.22456/2527-2616.134965
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/dar/article/view/134965/91173
dc.rights.driver.fl_str_mv Copyright (c) 2023 Drug Analytical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Drug Analytical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Pharmaceutical analysis
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Sul
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Sul
dc.source.none.fl_str_mv Drug Analytical Research; Vol. 7 No. 2 (2023); 3-8
Drug Analytical Research; v. 7 n. 2 (2023); 3-8
2527-2616
reponame:Revista Drug Analytical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Revista Drug Analytical Research
collection Revista Drug Analytical Research
repository.name.fl_str_mv Revista Drug Analytical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv druganalyticalresearch@ufrgs.br
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score 15.301603

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