Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutio...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/68192 |
| Acceso en línea: | http://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000004/art00005 http://hdl.handle.net/11449/68192 |
| Access Level: | acceso abierto |
| Palabra clave: | excipient gatifloxacin quinoline derived antiinfective agent accuracy analytic method aqueous solution calibration correlation coefficient drug determination linear regression analysis reproducibility statistical analysis tablet formulation ultraviolet spectrophotometry validation process Anti-Infective Agents Calibration Fluoroquinolones Reference Standards Reproducibility of Results Spectrophotometry, Ultraviolet Tablets |
| Sumario: | A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 μg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method. |
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