The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice

We evaluated the cyto/genotoxicity in peripheral blood of CD-1 mice exposed to different varieties of red wine Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo. Groups of five CD-1 mice were treated with: a) vehicle only; b) red wine or ethanol ad libitum (diluted 75% and 10%, r...

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Authors: García-Rodríguez, Maria del Carmen, Guerrero-Palomo, Gabriela, Altamirano-Lozano, Mario
Format: article
Status:Published version
Publication Date:2017
Country:México
Institution:UNIVERSIDAD DE GUANAJUATO
Repository:Acta Universitaria
Language:Spanish
OAI Identifier:oai:www.actauniversitaria.ugto.mx:article/1221
Online Access:https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221
Access Level:Open access
Keyword:Vino tinto
genotoxicidad
micronúcleos
citotoxicidad
alcohol.
Red wine
genotoxicity
micronucleus
cytotoxicity
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spelling The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 miceEfecto de la administración intragástrica y ad libitum del vino tinto (Cabernet sauvignon, Merlot, Carménère y Cabernet sauvignon/Nebbiolo) y del alcohol en la cito/genotoxicidad evaluada en sangre periférica de ratones CD-1García-Rodríguez, Maria del CarmenGuerrero-Palomo, GabrielaAltamirano-Lozano, MarioVino tintogenotoxicidadmicronúcleoscitotoxicidadalcohol.Red winegenotoxicitymicronucleuscytotoxicityalcohol.We evaluated the cyto/genotoxicity in peripheral blood of CD-1 mice exposed to different varieties of red wine Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo. Groups of five CD-1 mice were treated with: a) vehicle only; b) red wine or ethanol ad libitum (diluted 75% and 10%, respectively); c) undiluted red wine or ethanol diluted to 13.5% (two daily doses-0.25 ml via intragastric [i.g.]). The cyto/genotoxicity was evaluated by micronucleus (MN) assay, and by the relationship between polychromatic/monochromatic erythrocytes at 0 h, 24 h, 48 h and 72 h. Significant but slight increases of MN were observed only in the treatments i.g. of Cabernet Sauvignon, Merlot, and ethanol. However, the administration ad libitum of red wines tended to decrease the MN. Our findings suggest that the MN could be related with the bioavailability, pharmacodynamics, and pharmacokinetics of ethanol and the antioxidants of red wine. No cytotoxic effects were observed.Se evaluó la cito/genotoxicidad en sangre periférica de ratones CD-1 expuestos a diferentes variedades de vino tinto (Cabernet Sauvignon, Merlot, Carménère y Cabernet Sauvignon/Nebbiolo). Grupos de cinco organismos fueron tratados: a) con el vehículo, b) vino tinto o etanol (diluidos al 75 y 10%, respectivamente) ad libitum, y c) vino tinto sin diluir o etanol diluido al 13.5% (dos dosis diarias-0.25 ml, vía i.g.). La genotoxicidad se evaluó con los micronúcleos (MN) y la citotoxicidad con la relación entre eritrocitos policromáticos/normocromáticos (EPC/ENC) a las 0, 24, 48 y 72 h. Solo se observaron incrementos significativos en los MN con los tratamientos i.g de Cabernet Sauvignon, Merlot y etanol, siendo mayor para el etanol. La administración ad libitum de los vinos tintos redujo los MN. Nuestros hallazgos sugieren que los efectos genotóxicos del vino tinto podrían estar relacionados con la biodisponibilidad, farmacodinámica y farmacocinética del etanol. No se observaron efectos citotóxicos.Universidad de Guanajuato2017-08-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículo revisado por parestext/htmlapplication/pdfapplication/xmlhttps://www.actauniversitaria.ugto.mx/index.php/acta/article/view/122110.15174/au.2017.1221Acta Universitaria; Vol. 27 Núm. 3 (2017); 19-27Acta Universitaria; Vol. 27 No. 3 (2017); 19-272007-96210188-6266reponame:Acta Universitariainstname:UNIVERSIDAD DE GUANAJUATOinstacron:UGTOspahttps://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221/html_156https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221/pdfhttps://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221/3107info:eu-repo/semantics/openAccessoai:www.actauniversitaria.ugto.mx:article/12212024-08-16T21:06:34Z
dc.title.none.fl_str_mv The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
Efecto de la administración intragástrica y ad libitum del vino tinto (Cabernet sauvignon, Merlot, Carménère y Cabernet sauvignon/Nebbiolo) y del alcohol en la cito/genotoxicidad evaluada en sangre periférica de ratones CD-1
title The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
spellingShingle The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
García-Rodríguez, Maria del Carmen
Vino tinto
genotoxicidad
micronúcleos
citotoxicidad
alcohol.
Red wine
genotoxicity
micronucleus
cytotoxicity
alcohol.
title_short The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
title_full The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
title_fullStr The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
title_full_unstemmed The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
title_sort The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice
dc.creator.none.fl_str_mv García-Rodríguez, Maria del Carmen
Guerrero-Palomo, Gabriela
Altamirano-Lozano, Mario
author García-Rodríguez, Maria del Carmen
author_facet García-Rodríguez, Maria del Carmen
Guerrero-Palomo, Gabriela
Altamirano-Lozano, Mario
author_role author
author2 Guerrero-Palomo, Gabriela
Altamirano-Lozano, Mario
author2_role author
author
dc.subject.none.fl_str_mv Vino tinto
genotoxicidad
micronúcleos
citotoxicidad
alcohol.
Red wine
genotoxicity
micronucleus
cytotoxicity
alcohol.
topic Vino tinto
genotoxicidad
micronúcleos
citotoxicidad
alcohol.
Red wine
genotoxicity
micronucleus
cytotoxicity
alcohol.
description We evaluated the cyto/genotoxicity in peripheral blood of CD-1 mice exposed to different varieties of red wine Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo. Groups of five CD-1 mice were treated with: a) vehicle only; b) red wine or ethanol ad libitum (diluted 75% and 10%, respectively); c) undiluted red wine or ethanol diluted to 13.5% (two daily doses-0.25 ml via intragastric [i.g.]). The cyto/genotoxicity was evaluated by micronucleus (MN) assay, and by the relationship between polychromatic/monochromatic erythrocytes at 0 h, 24 h, 48 h and 72 h. Significant but slight increases of MN were observed only in the treatments i.g. of Cabernet Sauvignon, Merlot, and ethanol. However, the administration ad libitum of red wines tended to decrease the MN. Our findings suggest that the MN could be related with the bioavailability, pharmacodynamics, and pharmacokinetics of ethanol and the antioxidants of red wine. No cytotoxic effects were observed.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artículo revisado por pares
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221
10.15174/au.2017.1221
url https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221
identifier_str_mv 10.15174/au.2017.1221
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221/html_156
https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221/pdf
https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1221/3107
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
application/pdf
application/xml
dc.publisher.none.fl_str_mv Universidad de Guanajuato
publisher.none.fl_str_mv Universidad de Guanajuato
dc.source.none.fl_str_mv Acta Universitaria; Vol. 27 Núm. 3 (2017); 19-27
Acta Universitaria; Vol. 27 No. 3 (2017); 19-27
2007-9621
0188-6266
reponame:Acta Universitaria
instname:UNIVERSIDAD DE GUANAJUATO
instacron:UGTO
instname_str UNIVERSIDAD DE GUANAJUATO
instacron_str UGTO
institution UGTO
reponame_str Acta Universitaria
collection Acta Universitaria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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