La inhibición del ciclo celular y el cambio en el estado redox como factores determinantes durante el establecimiento del fenómeno de senescencia en fibroblastos de ratón
Senescence phenotype can be achieved by multiple pathways. Most of them involve the activation of negative cell cycle regulators as well as a shift to an oxidative status. However, the exact participation of these events in senescence establishment and maintenance is not completely understood. In th...
| Autor: | |
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | México |
| Institución: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:n583xv16z |
| Acceso en línea: | https://doi.org/10.24275/uami.n583xv16z |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/LEM/Oxidation-reduction reaction info:eu-repo/classification/LEM/Reacción de oxidación-reducción info:eu-repo/classification/LEM/Ciclo celular info:eu-repo/classification/LEM/Cells -- Aging info:eu-repo/classification/LEM/Biología experimental info:eu-repo/classification/LEM/Células -- Envejecimiento info:eu-repo/classification/LEM/Cell cycle info:eu-repo/classification/LEM/Biology, Experimental info:eu-repo/classification/cti/3 |
| Sumario: | Senescence phenotype can be achieved by multiple pathways. Most of them involve the activation of negative cell cycle regulators as well as a shift to an oxidative status. However, the exact participation of these events in senescence establishment and maintenance is not completely understood. In this study we investigated the content of three final cell cycle regulators, as well as the redox state in some critical points during the pre-senescent and the full senescent states. The results highlight the existence of a critical pre-phase in senescent phenotype establishment, in which cell proliferation stops with the participation of the cell cycle inhibitors, and a second maintenance stage where the exacerbated pro-oxidant state inside the cell induces the physiological decline characteristic in senescent cells. |
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