Efecto del extracto de mezquite (prosopis juliflora) en la fisiología reproductiva de la rata
Mesquite (Prosopis julilflora) is a legume which is distributed in the arid and semi-arid zones of Mexico and is widely used for feeding various species of livestock and even in human diet due to its high content of proteins, carbohydrates, fiber, vitamins and minerals. Mesquite also contains differ...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | México |
| Institución: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:nz805z91h |
| Acceso en línea: | https://doi.org/10.24275/uami.nz805z91h |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/LEM/Phytoestrogens -- Physiological effect info:eu-repo/classification/LEM/Prosopis juliflora info:eu-repo/classification/LEM/Fitoestrógenos info:eu-repo/classification/LEM/Extracto de mezquite info:eu-repo/classification/LEM/Reproducción animal info:eu-repo/classification/LEM/Rats -- Reproduction info:eu-repo/classification/LEM/Ratas info:eu-repo/classification/LEM/Reproduction -- Animals info:eu-repo/classification/LEM/Mesquite info:eu-repo/classification/cti/6 |
| Sumario: | Mesquite (Prosopis julilflora) is a legume which is distributed in the arid and semi-arid zones of Mexico and is widely used for feeding various species of livestock and even in human diet due to its high content of proteins, carbohydrates, fiber, vitamins and minerals. Mesquite also contains different types of phytoestrogens, which are plant chemical compounds structurally similar to estradiol. This allows their binding with Estrogen receptors (ERs), thus promoting estrogenic effects, which can cause negative effects in the reproduction of several species of mammals. Therefore, the aim of this study was to evaluate the effectsof the administration of mesquite pod extract on the reproduction of female and male rats, as well as their repercussions on fertility. Female and male Wistar rats were randomly assigned to one of the following experimental groups: control (CON), mesquite pod extract (MEZ), daidzein (DAI) and estradiol (E2). The treatments were administered subcutaneously for thirty consecutive days. The females receiving MEZ showed an elongation in their estrous cycle, withincrease in the number of days in metaestrus and estrus. In contrast, the lordotic quotient and intensity of lordosis decreased due to the effect of MEZ, while the weight of the vagina of females in proestrus and diestrus was greaterthan control. The height of the uterine and vaginal epithelium during proestrus and diestrus was greater in females treated with MEZ. Conversely, serum progesterone (P4) levels decreased. In the case of the males treated with MEZ,the numbers of ejaculations decreased, and mount latency increased. Male sex glands weight was lower in rats treated with MEZ, and testicular weight, sperm quality and testosterone concentration decreased in this group. Conversely, the number of TUNEL-positive germ cells and the percentage of seminiferous tubules containing TUNEL-positive germ cells increased with the treatment of MEZ. The effects observed in males treated with MEZ were similar to those caused by DAI treatment, although less intense than the effects generated by E2. The results in this work show that the mesquite pod extract is capable of induce alterations in reproductive parameters, both in males and females, causing a decrease in fertil. |
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