Efecto de la sobreexpresión de miosina 1G sobre la migración de linfocitos B y su correlación con la gravedad de la leucemia linfoblástica aguda
Leukemia is the most common cancer in children.It is characterized by infiltration of the bone marrow and other tissues; the presence of infiltrations is of bad prognosis and correlates with increased severity in patients. Acute lymphoblastic leukemia (ALL) is the most frequent in children under 15...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | México |
| Institución: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:9019s311r |
| Acceso en línea: | https://doi.org/10.24275/uami.9019s311r |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/LEM/Leucemia linfoblástica info:eu-repo/classification/LEM/Myosin info:eu-repo/classification/LEM/Lymphoblastic leukemia info:eu-repo/classification/LEM/Miosina info:eu-repo/classification/cti/3 |
| Sumario: | Leukemia is the most common cancer in children.It is characterized by infiltration of the bone marrow and other tissues; the presence of infiltrations is of bad prognosis and correlates with increased severity in patients. Acute lymphoblastic leukemia (ALL) is the most frequent in children under 15 years, constitutes25% of all the cancers diagnosed in this age group and affects B and T cell lineages. Myosin 1G is a motor protein expressed below the membrane of hematopoietic cells, mainly in lymphocytes; in these cells this protein has an important role in migration. Results from an analysis of a microarray database, showed that myosin1G is overexpressed in leukemias. The main goal of this study was to analyze if Myo1Gwas overexpressed in children with leukemia and determine if Myo 1G could function as a biomarker for this disease. To begin to address this we included 13 high-risk patients, 13 normal risk patients, 2 patients with acute lymphoblastic leukemia without risk classification, 5 patients with acute myeloblastic leukemia and 10 pediatric healthy individuals. Our results show that the expression of myosin 1G increases in high risk children and we propose that the increased myosin 1G expression could be associated with the promotion of infiltrates, our hypothesis isthat the cell moves with higher speed from one place to another, but we consider that is necessary to increase our pediatric population with that diagnosis so we obtain more robust results. |
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