Microwave-assisted High Diastereoselective Synthesis of (alpha)- Aminophosphonates under Solvent and Catalyst Free-conditions
A simple, efficient and general method has been developed for the high diastereoselective synthesis of a-aminophosphonates through "one-pot" three-component reaction of alkyl and aryl aldehydes with (S)-a-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik-...
| Authors: | , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2012 |
| Country: | México |
| Institution: | Universidad Autónoma del Estado de Morelos |
| Repository: | Redalyc-UAEM |
| OAI Identifier: | oai:redalyc.org:47523306017 |
| Online Access: | https://www.redalyc.org/articulo.oa?id=47523306017 |
| Access Level: | Open access |
| Keyword: | Química Three Microwave Green Chemistry aminophosphonates component Reaction |
| Summary: | A simple, efficient and general method has been developed for the high diastereoselective synthesis of a-aminophosphonates through "one-pot" three-component reaction of alkyl and aryl aldehydes with (S)-a-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik-Fields reaction), which proceeds in short time using microwave irradiation under solvent and catalyst free-conditions. This method could be useful in the large-scale synthesis of a-aminophosphonates in short reaction time. |
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