Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel-Crafts Reaction

Chiral phosphoric acids efficiently catalyze the asymmetric Friedel−Crafts reaction of several indoles with α-iminophosphonates to afford enantioenriched hybrid α-aminophosphonate functionalized indole derivatives.

Detalhes bibliográficos
Autores: Maestro Burzaco, Aitor, Martínez de Marigorta Izaga, Edorta, Palacios Gambra, Francisco Javier, Vicario Hernando, Javier
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/70039
Acesso em linha:http://hdl.handle.net/10810/70039
Access Level:acceso abierto
Palavra-chave:asymmetric organocatalysis
Friedel-Crafts
alpha-aminophosphonates
indole
chiral phosphoric acids
Descrição
Resumo:Chiral phosphoric acids efficiently catalyze the asymmetric Friedel−Crafts reaction of several indoles with α-iminophosphonates to afford enantioenriched hybrid α-aminophosphonate functionalized indole derivatives.