Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in...

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Detalhes bibliográficos
Autores: Marazuela, Paula, Bonaterra-Pastra, Anna, Faura, Julia, Penalba, Anna, Pizarro, Jesus, Pancorbo, Olalla, Rodriguez-Luna, David, Vert, Carla, Rovira, Alex, Pujadas, Francesc, Freijo Guerrero, Maria del Mar, Tur Campos, Silvia, Martinez-Zabaleta, Maite, Cardona Portela, Pere, Vera, Rocío, Lebrato-Hernandez, Lucia, Arenillas, Juan Francisco, Perez-Sanchez, Soledad, Montaner, Joan, Delgado, Pilar, Hernandez-Guillamon, Mar
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19492
Acesso em linha:https://hdl.handle.net/20.500.13003/19492
Access Level:acceso abierto
Palavra-chave:aquaporin 4
cerebral amyloid angiopathy
intracerebral hemorrhage
magnetic resonance imaging markers
functional outcome
Descrição
Resumo:Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 +/- 18.6 months) and long-term (38.5 +/- 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as >= 2 lobar ICHs and >= 5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.

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