Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in...

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Detalles Bibliográficos
Autores: Marazuela, Paula, Bonaterra Pastra, Anna, Faura, Júlia, Penalba, Anna, Pizarro, Jesús, Pancorbo, Olalla, Rodríguez Luna, David, Vert, Carla, Rovira, Alex, Pujadas, Francesc, Freijo, M. Mar, Tur, Silvia, Martínez Zabaleta, Maite, Cardona Portela, Pere, Vera, Rocío, Lebrato Hernández, Lucia, Arenillas, Juan F., Pérez Sánchez, Soledad, Montaner, Joan, Delgado, Pilar, Hernández Guillamon, Mar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/175995
Acceso en línea:https://hdl.handle.net/2445/175995
Access Level:acceso abierto
Palabra clave:Hemorràgia
Malalties del sistema nerviós central
Ressonància magnètica
Hemorrhage
Central nervous system diseases
Magnetic resonance
Descripción
Sumario:Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 +/- 18.6 months) and long-term (38.5 +/- 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as >= 2 lobar ICHs and >= 5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.

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