Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in...

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Autores: Marazuela, Paula|||0000-0003-1038-5242, Bonaterra-Pastra, Anna|||0000-0002-1480-622X, Faura, Júlia|||0000-0002-8436-1377, Penalba, Anna, Pizarro Gonzálvez, Jesús|||0000-0002-5808-9293, Pancorbo, Olalla|||0000-0003-3240-4862, Rodriguez-Luna, David|||0000-0001-8053-4536, Vert, Carla, Rovira, Alex|||0000-0002-2132-6750, Pujadas, Francesc|||0000-0003-3569-2601, Freijo, M. Mar, Tur, Silvia, Martínez-Zabaleta, Maite, Cardona, Pere-Joan|||0000-0001-5623-7873, Vera, Rocío, Lebrato-Hernández, Lucia|||0000-0002-3541-0697, Arenillas, Juan F.|||0000-0001-7464-6101, Pérez-Sánchez, Soledad|||0000-0002-8940-9763, Montaner, Joan|||0000-0003-4845-2279, Delgado Martínez, María Pilar|||0000-0002-1628-4488, Hernandez Guillamon, Maria Mar|||0000-0001-8844-0091
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255406
Acceso en línea:https://ddd.uab.cat/record/255406
https://dx.doi.org/urn:doi:10.3390/jcm10050989
Access Level:acceso abierto
Palabra clave:Aquaporin 4
Cerebral amyloid angiopathy
Intracerebral hemorrhage
Magnetic resonance imaging markers
Functional outcome
Descripción
Sumario:Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.

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