Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations

Introduction: To evaluate the immediate effects of two artificial tear formulations—mineral oil + hydroxypropyl guar (HP-Guar) and hyaluronic acid (HA) + HP-Guar—on ocular aberrations in healthy participants. Methods: A randomized, participant-masked clinical trial was conducted on 98 right eyes of...

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Autores: Sánchez González, José María, Sánchez González, María del Carmen, Hita Cantalejo, María Concepción de, Nascimento, Henrique, Martínez Pérez, Clara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/176941
Acceso en línea:https://hdl.handle.net/11441/176941
https://doi.org/10.1007/s40123-025-01205-z
Access Level:acceso abierto
Palabra clave:Ocular aberrations
Lipid eye drops
Mineral oil
Hydroxypropyl guar
Hyaluronic acid
Non-lipid eye drops
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spelling Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar FormulationsSánchez González, José MaríaSánchez González, María del CarmenHita Cantalejo, María Concepción deNascimento, HenriqueMartínez Pérez, ClaraOcular aberrationsLipid eye dropsMineral oilHydroxypropyl guarHyaluronic acidNon-lipid eye dropsIntroduction: To evaluate the immediate effects of two artificial tear formulations—mineral oil + hydroxypropyl guar (HP-Guar) and hyaluronic acid (HA) + HP-Guar—on ocular aberrations in healthy participants. Methods: A randomized, participant-masked clinical trial was conducted on 98 right eyes of 98 participants (mean age: 27.96 ± 10.00 years). Participants received a single instillation of either a lipid-based (mineral oil + HP-Guar) or non-lipid (HA + HP-Guar) artificial tear solution. Ocular aberrations were measured before and 10 min post-instillation using a wavefront aberrometer (i.Profilerplus®, Carl Zeiss Meditec, Jena, Germany) at pupil diameters of 3 mm and 5 mm. Root mean square (RMS) values for total, low-order, and high-order aberrations were analyzed. Results: The mineral oil + HP-Guar formulation significantly reduced total RMS (p < 0.05) and low-order RMS (p < 0.05) at both 3-mm and 5-mm pupil diameters. Notable reductions were observed in defocus (Z2 0), vertical astigmatism (Z2 2), and trefoil (Z3 −3). Both formulations significantly increased high-order RMS (p < 0.05). Conclusions: Lipid-based artificial tears provide superior optical quality by reducing total and low-order ocular aberrations, making them preferable for patients with tear film instability. In contrast, HA-based formulations primarily improve hydration with limited impact on optical performance. Artificial tear selection should consider both symptomatic relief and refractive stability, especially for individuals with high visual demands.Springer Nature LinkFísica de la Materia CondensadaCTS1040: Ciencias de la Visión2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/176941https://doi.org/10.1007/s40123-025-01205-zreponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésOphthalmology & Therapy, 14, 2165-2178.https://link.springer.com/article/10.1007/s40123-025-01205-zinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1769412026-06-17T12:51:07Z
dc.title.none.fl_str_mv Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
title Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
spellingShingle Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
Sánchez González, José María
Ocular aberrations
Lipid eye drops
Mineral oil
Hydroxypropyl guar
Hyaluronic acid
Non-lipid eye drops
title_short Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
title_full Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
title_fullStr Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
title_full_unstemmed Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
title_sort Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
dc.creator.none.fl_str_mv Sánchez González, José María
Sánchez González, María del Carmen
Hita Cantalejo, María Concepción de
Nascimento, Henrique
Martínez Pérez, Clara
author Sánchez González, José María
author_facet Sánchez González, José María
Sánchez González, María del Carmen
Hita Cantalejo, María Concepción de
Nascimento, Henrique
Martínez Pérez, Clara
author_role author
author2 Sánchez González, María del Carmen
Hita Cantalejo, María Concepción de
Nascimento, Henrique
Martínez Pérez, Clara
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Física de la Materia Condensada
CTS1040: Ciencias de la Visión
dc.subject.none.fl_str_mv Ocular aberrations
Lipid eye drops
Mineral oil
Hydroxypropyl guar
Hyaluronic acid
Non-lipid eye drops
topic Ocular aberrations
Lipid eye drops
Mineral oil
Hydroxypropyl guar
Hyaluronic acid
Non-lipid eye drops
description Introduction: To evaluate the immediate effects of two artificial tear formulations—mineral oil + hydroxypropyl guar (HP-Guar) and hyaluronic acid (HA) + HP-Guar—on ocular aberrations in healthy participants. Methods: A randomized, participant-masked clinical trial was conducted on 98 right eyes of 98 participants (mean age: 27.96 ± 10.00 years). Participants received a single instillation of either a lipid-based (mineral oil + HP-Guar) or non-lipid (HA + HP-Guar) artificial tear solution. Ocular aberrations were measured before and 10 min post-instillation using a wavefront aberrometer (i.Profilerplus®, Carl Zeiss Meditec, Jena, Germany) at pupil diameters of 3 mm and 5 mm. Root mean square (RMS) values for total, low-order, and high-order aberrations were analyzed. Results: The mineral oil + HP-Guar formulation significantly reduced total RMS (p < 0.05) and low-order RMS (p < 0.05) at both 3-mm and 5-mm pupil diameters. Notable reductions were observed in defocus (Z2 0), vertical astigmatism (Z2 2), and trefoil (Z3 −3). Both formulations significantly increased high-order RMS (p < 0.05). Conclusions: Lipid-based artificial tears provide superior optical quality by reducing total and low-order ocular aberrations, making them preferable for patients with tear film instability. In contrast, HA-based formulations primarily improve hydration with limited impact on optical performance. Artificial tear selection should consider both symptomatic relief and refractive stability, especially for individuals with high visual demands.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/176941
https://doi.org/10.1007/s40123-025-01205-z
url https://hdl.handle.net/11441/176941
https://doi.org/10.1007/s40123-025-01205-z
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Ophthalmology & Therapy, 14, 2165-2178.
https://link.springer.com/article/10.1007/s40123-025-01205-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Nature Link
publisher.none.fl_str_mv Springer Nature Link
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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