Immediate Impact of Artificial Tear Composition on Optical Aberrations: A Comparative Study of Lipid and Non‑Lipid Hydroxypropyl Guar Formulations
Introduction: To evaluate the immediate effects of two artificial tear formulations—mineral oil + hydroxypropyl guar (HP-Guar) and hyaluronic acid (HA) + HP-Guar—on ocular aberrations in healthy participants. Methods: A randomized, participant-masked clinical trial was conducted on 98 right eyes of...
| Autores: | , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2025 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositório: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/176941 |
| Acesso em linha: | https://hdl.handle.net/11441/176941 https://doi.org/10.1007/s40123-025-01205-z |
| Access Level: | Acceso aberto |
| Palavra-chave: | Ocular aberrations Lipid eye drops Mineral oil Hydroxypropyl guar Hyaluronic acid Non-lipid eye drops |
| Resumo: | Introduction: To evaluate the immediate effects of two artificial tear formulations—mineral oil + hydroxypropyl guar (HP-Guar) and hyaluronic acid (HA) + HP-Guar—on ocular aberrations in healthy participants. Methods: A randomized, participant-masked clinical trial was conducted on 98 right eyes of 98 participants (mean age: 27.96 ± 10.00 years). Participants received a single instillation of either a lipid-based (mineral oil + HP-Guar) or non-lipid (HA + HP-Guar) artificial tear solution. Ocular aberrations were measured before and 10 min post-instillation using a wavefront aberrometer (i.Profilerplus®, Carl Zeiss Meditec, Jena, Germany) at pupil diameters of 3 mm and 5 mm. Root mean square (RMS) values for total, low-order, and high-order aberrations were analyzed. Results: The mineral oil + HP-Guar formulation significantly reduced total RMS (p < 0.05) and low-order RMS (p < 0.05) at both 3-mm and 5-mm pupil diameters. Notable reductions were observed in defocus (Z2 0), vertical astigmatism (Z2 2), and trefoil (Z3 −3). Both formulations significantly increased high-order RMS (p < 0.05). Conclusions: Lipid-based artificial tears provide superior optical quality by reducing total and low-order ocular aberrations, making them preferable for patients with tear film instability. In contrast, HA-based formulations primarily improve hydration with limited impact on optical performance. Artificial tear selection should consider both symptomatic relief and refractive stability, especially for individuals with high visual demands. |
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