The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex

We describe the case of a participant in a clinical trial investigating intracortical microstimulation of the visual cortex to provide a limited yet functional sense of vision to the profoundly blind. Prior to his formal enrolment, he was completely blind due to bilateral Non-arteritic Anterior Isch...

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Authors: Alfaro, A, Soo, L, Waclawczyk, D, Morollón, R, Grani, F, Fernandez, E
Format: article
Status:Published version
Publication Date:2026
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:dnet:r-fisabio___::3234b91a3439677c19382c5ef9bd8da0
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/20654
Access Level:Open access
Keyword:electrical stimulation
visual cortex
artificial vision
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spelling The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortexAlfaro, ASoo, LWaclawczyk, DMorollón, RGrani, FFernandez, Eelectrical stimulationvisual cortexartificial visionWe describe the case of a participant in a clinical trial investigating intracortical microstimulation of the visual cortex to provide a limited yet functional sense of vision to the profoundly blind. Prior to his formal enrolment, he was completely blind due to bilateral Non-arteritic Anterior Ischemic Optic Neuropathy. Following the initiation of brain electrical microstimulation experiments, he experienced a remarkable recovery of spontaneous vision. The regained sight, after more than 3 years of complete blindness, enabled him to perceive light and motion again and even read large characters and words, enhancing his confidence in mobility and daily activities. We conducted several behavioural and electrophysiological tests to assess and quantify his vision over time. Alfaro et al. report the case of a blind individual who participated in a clinical trial involving intracortical microstimulation of the visual cortex. Following electrical stimulation, the participant experienced a significant recovery of vision, enabling light perception, motion detection and reading of large characters, thus improving mobility and daily activities. 10.1093/brain/fcaf504_video1 Video Abstract fcaf504media1 6388674390112OXFORD UNIV PRESS2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/20654Brain CommunicationsISSN: 26321297reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:dnet:r-fisabio___::3234b91a3439677c19382c5ef9bd8da02026-06-11T12:45:17Z
dc.title.none.fl_str_mv The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
title The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
spellingShingle The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
Alfaro, A
electrical stimulation
visual cortex
artificial vision
title_short The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
title_full The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
title_fullStr The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
title_full_unstemmed The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
title_sort The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex
dc.creator.none.fl_str_mv Alfaro, A
Soo, L
Waclawczyk, D
Morollón, R
Grani, F
Fernandez, E
author Alfaro, A
author_facet Alfaro, A
Soo, L
Waclawczyk, D
Morollón, R
Grani, F
Fernandez, E
author_role author
author2 Soo, L
Waclawczyk, D
Morollón, R
Grani, F
Fernandez, E
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv electrical stimulation
visual cortex
artificial vision
topic electrical stimulation
visual cortex
artificial vision
description We describe the case of a participant in a clinical trial investigating intracortical microstimulation of the visual cortex to provide a limited yet functional sense of vision to the profoundly blind. Prior to his formal enrolment, he was completely blind due to bilateral Non-arteritic Anterior Ischemic Optic Neuropathy. Following the initiation of brain electrical microstimulation experiments, he experienced a remarkable recovery of spontaneous vision. The regained sight, after more than 3 years of complete blindness, enabled him to perceive light and motion again and even read large characters and words, enhancing his confidence in mobility and daily activities. We conducted several behavioural and electrophysiological tests to assess and quantify his vision over time. Alfaro et al. report the case of a blind individual who participated in a clinical trial involving intracortical microstimulation of the visual cortex. Following electrical stimulation, the participant experienced a significant recovery of vision, enabling light perception, motion detection and reading of large characters, thus improving mobility and daily activities. 10.1093/brain/fcaf504_video1 Video Abstract fcaf504media1 6388674390112
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/20654
url https://fisabio.portalinvestigacion.com/publicaciones/20654
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv Brain Communications
ISSN: 26321297
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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