Long-interval intracortical inhibition in primary motor cortex related to working memory in middle-aged adults

Excitability of the primary motor cortex measured with TMS has been associated with cognitive dysfunctions in patient populations. However, only a few studies have explored this relationship in healthy adults, and even fewer have considered the role of biological sex. Ninety-seven healthy middle-age...

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Detalles Bibliográficos
Autores: Redondo-Camós, María|||0000-0002-3890-5070, Cattaneo, Gabriele|||0000-0002-7411-6829, Alviarez-Schulze, Vanessa|||0000-0002-9702-8688, Delgado-Gallén, Selma|||0000-0003-3763-9775, España-Irla, Goretti|||0000-0003-2525-6523, Solana-Sánchez, Javier|||0000-0003-0880-7856, Perellón-Alfonso, Ruben|||0000-0001-8647-3703, Albu, Sergiu|||0000-0001-8310-4208, Tormos, Jose M.|||0000-0002-8764-2289, Pascual Leone, Álvaro|||0000-0001-8975-0382, Bartrés-Faz, David|||0000-0001-6020-4118
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:282696
Acceso en línea:https://ddd.uab.cat/record/282696
https://dx.doi.org/urn:doi:10.3389/fpsyg.2022.998062
Access Level:acceso abierto
Palabra clave:Cognition
Electromyography
Long-interval cortical inhibition
Motor cortex
Resting motor threshold
Transcranial magnetic stimulation
Descripción
Sumario:Excitability of the primary motor cortex measured with TMS has been associated with cognitive dysfunctions in patient populations. However, only a few studies have explored this relationship in healthy adults, and even fewer have considered the role of biological sex. Ninety-seven healthy middle-aged adults (53 male) completed a TMS protocol and a neuropsychological assessment. Resting Motor Threshold (RMT) and Long-Interval Intracortical Inhibition (LICI) were assessed in the left motor cortex and related to attention, episodic memory, working memory, reasoning, and global cognition composite scores to evaluate the relationship between cortical excitability and cognitive functioning. In the whole sample, there was a significant association between LICI and cognition; specifically, higher motor inhibition was related to better working memory performance. When the sample was broken down by biological sex, LICI was only associated with working memory, reasoning, and global cognition in men. No associations were found between RMT and cognitive functions. Greater intracortical inhibition, measured by LICI, could be a possible marker of working memory in healthy middle-aged adults, and biological sex plays a critical role in this association.

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