Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer

The term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA derived fragments (tRFs and rRFs, respectively) are an emerging class of ncRNAs originally considered as simple degradation p...

Full description

Bibliographic Details
Authors: Rosace, Domenico, López, Judith, Blanco, Sandra
Format: article
Status:Versión aceptada para publicación
Publication Date:2020
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/202357
Online Access:http://hdl.handle.net/10261/202357
Access Level:Open access
Keyword:Transfer RNA fragments
Ribosomal RNA fragments
tRFs
rRFs
tRNA cleavage
Stress-induced tRNA cleavage
Translation initiation
Immune system
Cancer
id ES_facfb80a2d974aaf2dd22ece05165f71
oai_identifier_str oai:digital.csic.es:10261/202357
network_acronym_str ES
network_name_str España
repository_id_str
spelling Emerging roles of novel small non-coding regulatory RNAs in immunity and cancerRosace, DomenicoLópez, JudithBlanco, SandraTransfer RNA fragmentsRibosomal RNA fragmentstRFsrRFstRNA cleavageStress-induced tRNA cleavageTranslation initiationImmune systemCancerThe term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA derived fragments (tRFs and rRFs, respectively) are an emerging class of ncRNAs originally considered as simple degradation products, which though play important roles in stress responses, signalling or gene expression. They control all levels of gene expression regulating transcription and translation and affecting RNA processing and maturation. They have been linked to pivotal cellular processes such as self-renewal, differentiation and proliferation. For this reason, mis-regulation of this novel class of ncRNAs can lead to various pathological processes such as neurodegenerative and development diseases, metabolism and immune system disorders and cancer. In this review we summarize the classification, biogenesis and functions of tRFs and rRFs with a special focus on their role in immunity and cancer.D.R. is supported by Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia co-funded by the Castilla–León autonomous government and the European Regional Development Fund (CLC–2017–01). J.L. is a PhD student supported by a The Scientific Foundation AECC (Spanish Association Against Cancer) PhD fellowship (PRDSA19002LÓPE). S.B. is a Research Scientist of the Spanish Research Council. We acknowledge funding from the Spanish Ministry of Economy and Innovation (MINECO) and Agencia Estatal de Investigación (AEI) and co-financed by the European Development Regional Fund (FEDER) under grant no. SAF2016-78667-R (AEI/FEDER, UE). In addition we acknowledge funding from The Scientific Foundation AECC under grant no. LABAE19040BLAN, and the University of Salamanca and Fundación Memoria de Samuel Solorzano Barruso under grant no. FS/21-2018. AUTHOR’s institution is supported by the Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia cofunded by the Castilla–León autonomous government and the European Regional Development Fund (CLC–2017–01).Peer reviewedTaylor & FrancisJunta de Castilla y LeónEuropean CommissionConsejo Superior de Investigaciones Científicas (España)Ministerio de Economía y Competitividad (España)Universidad de SalamancaFundación Memoria de D. Samuel Solorzano BarrusoConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPostprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/202357reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-78667-Rhttps://doi.org/10.1080/15476286.2020.1737442Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2023572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
title Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
spellingShingle Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
Rosace, Domenico
Transfer RNA fragments
Ribosomal RNA fragments
tRFs
rRFs
tRNA cleavage
Stress-induced tRNA cleavage
Translation initiation
Immune system
Cancer
title_short Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
title_full Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
title_fullStr Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
title_full_unstemmed Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
title_sort Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
dc.creator.none.fl_str_mv Rosace, Domenico
López, Judith
Blanco, Sandra
author Rosace, Domenico
author_facet Rosace, Domenico
López, Judith
Blanco, Sandra
author_role author
author2 López, Judith
Blanco, Sandra
author2_role author
author
dc.contributor.none.fl_str_mv Junta de Castilla y León
European Commission
Consejo Superior de Investigaciones Científicas (España)
Ministerio de Economía y Competitividad (España)
Universidad de Salamanca
Fundación Memoria de D. Samuel Solorzano Barruso
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Transfer RNA fragments
Ribosomal RNA fragments
tRFs
rRFs
tRNA cleavage
Stress-induced tRNA cleavage
Translation initiation
Immune system
Cancer
topic Transfer RNA fragments
Ribosomal RNA fragments
tRFs
rRFs
tRNA cleavage
Stress-induced tRNA cleavage
Translation initiation
Immune system
Cancer
description The term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA derived fragments (tRFs and rRFs, respectively) are an emerging class of ncRNAs originally considered as simple degradation products, which though play important roles in stress responses, signalling or gene expression. They control all levels of gene expression regulating transcription and translation and affecting RNA processing and maturation. They have been linked to pivotal cellular processes such as self-renewal, differentiation and proliferation. For this reason, mis-regulation of this novel class of ncRNAs can lead to various pathological processes such as neurodegenerative and development diseases, metabolism and immune system disorders and cancer. In this review we summarize the classification, biogenesis and functions of tRFs and rRFs with a special focus on their role in immunity and cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/202357
url http://hdl.handle.net/10261/202357
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-78667-R
https://doi.org/10.1080/15476286.2020.1737442
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425272407719936
score 15.81155

Similar Items