SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity

The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enr...

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Autores: Trinité, Benjamin, Tarrés-Freixas, Ferran, Rodon, Jordi, Pradenas, Edwards, Urrea, Víctor, Marfil, Silvia, Rodríguez de la Concepción, María Luisa, Ávila-Nieto, Carlos, Aguilar-Gurrieri, Carmen, Barajas, Ana, Ortiz, Raquel, Paredes, Roger, Mateu, Lourdes, Valencia, Alfonso, Guallar, Víctor, Ruiz, Lidia, Grau, Eulàlia, Massanella, Marta, Puig, Jordi, Chamorro, Anna, Izquierdo-Useros, Nuria, Segalés, Joaquim, Clotet, Bonaventura, Carrillo, Jorge, Serra Gironella, Joan, Blanco, Julià
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12327/1226
Acceso en línea:http://hdl.handle.net/20.500.12327/1226
https://doi.org/10.1038/s41598-021-81862-9
Access Level:acceso abierto
Palabra clave:619
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network_acronym_str ES
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repository_id_str
spelling SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severityTrinité, BenjaminTarrés-Freixas, FerranRodon, JordiPradenas, EdwardsUrrea, VíctorMarfil, SilviaRodríguez de la Concepción, María LuisaÁvila-Nieto, CarlosAguilar-Gurrieri, CarmenBarajas, AnaOrtiz, RaquelParedes, RogerMateu, LourdesValencia, AlfonsoGuallar, VíctorRuiz, LidiaGrau, EulàliaMassanella, MartaPuig, JordiChamorro, AnnaIzquierdo-Useros, NuriaSegalés, JoaquimClotet, BonaventuraCarrillo, JorgeSerra Gironella, JoanBlanco, Julià619The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection.info:eu-repo/semantics/publishedVersionNature ResearchProducció AnimalSanitat Animal2021info:eu-repo/semantics/article10http://hdl.handle.net/20.500.12327/1226https://doi.org/10.1038/s41598-021-81862-9reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésScientific ReportsAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12327/12262026-05-29T05:05:01Z
dc.title.none.fl_str_mv SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
title SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
spellingShingle SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
Trinité, Benjamin
619
title_short SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
title_full SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
title_fullStr SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
title_full_unstemmed SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
title_sort SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
dc.creator.none.fl_str_mv Trinité, Benjamin
Tarrés-Freixas, Ferran
Rodon, Jordi
Pradenas, Edwards
Urrea, Víctor
Marfil, Silvia
Rodríguez de la Concepción, María Luisa
Ávila-Nieto, Carlos
Aguilar-Gurrieri, Carmen
Barajas, Ana
Ortiz, Raquel
Paredes, Roger
Mateu, Lourdes
Valencia, Alfonso
Guallar, Víctor
Ruiz, Lidia
Grau, Eulàlia
Massanella, Marta
Puig, Jordi
Chamorro, Anna
Izquierdo-Useros, Nuria
Segalés, Joaquim
Clotet, Bonaventura
Carrillo, Jorge
Serra Gironella, Joan
Blanco, Julià
author Trinité, Benjamin
author_facet Trinité, Benjamin
Tarrés-Freixas, Ferran
Rodon, Jordi
Pradenas, Edwards
Urrea, Víctor
Marfil, Silvia
Rodríguez de la Concepción, María Luisa
Ávila-Nieto, Carlos
Aguilar-Gurrieri, Carmen
Barajas, Ana
Ortiz, Raquel
Paredes, Roger
Mateu, Lourdes
Valencia, Alfonso
Guallar, Víctor
Ruiz, Lidia
Grau, Eulàlia
Massanella, Marta
Puig, Jordi
Chamorro, Anna
Izquierdo-Useros, Nuria
Segalés, Joaquim
Clotet, Bonaventura
Carrillo, Jorge
Serra Gironella, Joan
Blanco, Julià
author_role author
author2 Tarrés-Freixas, Ferran
Rodon, Jordi
Pradenas, Edwards
Urrea, Víctor
Marfil, Silvia
Rodríguez de la Concepción, María Luisa
Ávila-Nieto, Carlos
Aguilar-Gurrieri, Carmen
Barajas, Ana
Ortiz, Raquel
Paredes, Roger
Mateu, Lourdes
Valencia, Alfonso
Guallar, Víctor
Ruiz, Lidia
Grau, Eulàlia
Massanella, Marta
Puig, Jordi
Chamorro, Anna
Izquierdo-Useros, Nuria
Segalés, Joaquim
Clotet, Bonaventura
Carrillo, Jorge
Serra Gironella, Joan
Blanco, Julià
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Producció Animal
Sanitat Animal
dc.subject.none.fl_str_mv 619
topic 619
description The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12327/1226
https://doi.org/10.1038/s41598-021-81862-9
url http://hdl.handle.net/20.500.12327/1226
https://doi.org/10.1038/s41598-021-81862-9
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific Reports
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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