SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity

The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enr...

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Detalles Bibliográficos
Autores: Trinité, Benjamin|||0000-0003-3809-042X, Tarrés-Freixas, Ferran|||0000-0002-1569-0126, Rodon, Jordi|||0000-0002-1032-9091, Pradenas, Edwards|||0000-0001-5162-8920, Urrea, Víctor|||0000-0002-2577-856X, Marfil, Sílvia|||0000-0003-0139-5000, Rodriguez de la Concepción, Maria Luisa|||0000-0002-6944-3462, Avila-Nieto, Carlos, Aguilar-Gurrieri, Carmen|||0000-0002-5701-7650, Barajas Vélez, Ana|||0000-0003-1103-9499, Ortiz, Raquel|||0000-0002-6919-2026, Paredes, Roger|||0000-0002-6553-691X, Mateu, Lourdes|||0000-0001-7223-7611, Valencia, Alfonso|||0000-0002-8937-6789, Guallar, Victor|||0000-0002-4580-1114, Ruiz, Lidia, Grau, Eulàlia|||0000-0002-2442-9165, Massanella, Marta|||0000-0002-3326-151X, Puig, Jordi|||0000-0002-4075-0346, Chamorro, Anna, Izquierdo Useros, Nuria|||0000-0002-1039-1821, Segalés Coma, Joaquim|||0000-0002-1539-7261, Clotet Sala, Bonaventura|||0000-0003-3232-4598, Carrillo, Jorge|||0000-0003-0221-5948, Vergara-Alert, Júlia|||0000-0001-7484-444X, Blanco, Julià|||0000-0002-2225-0217
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252332
Acceso en línea:https://ddd.uab.cat/record/252332
https://dx.doi.org/urn:doi:10.1038/s41598-021-81862-9
Access Level:acceso abierto
Palabra clave:Infectious diseases
Immunology
Adaptive immunity
Descripción
Sumario:The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection.

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