Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals

With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudovi...

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Detalles Bibliográficos
Autores: Trinité, Benjamin, Pradenas, Edwards, Marfil, Silvia, Rovirosa, Carla, Urrea, Víctor, Tarrés-Freixas, Ferran, Ortiz, Raquel, Rodon, Jordi, Serra Gironella, Joan, Segalés, Joaquim, Guallar, Victor, Lepore, Rosalba, Izquierdo-Useros, Nuria, Trujillo, Glòria, Trapé, Jaume, González-Fernández, Carolina, Flor, Antonia, Pérez-Vidal, Rafel, Toledo, Ruth, Chamorro, Anna, Paredes, Roger, Blanco, Ignacio, Grau, Eulàlia, Massanella, Marta, Carrillo, Jorge, Clotet, Bonaventura, Blanco, Julià
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Repositorio:IRTA Pubpro. Open Digital Archive
OAI Identifier:oai:repositori.irta.cat:20.500.12327/1411
Acceso en línea:http://hdl.handle.net/20.500.12327/1411
https://doi.org/10.3390/v13061135
Access Level:acceso abierto
Palabra clave:619
Descripción
Sumario:With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.

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