pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery
The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many str...
| Authors: | , , |
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| Format: | article |
| Publication Date: | 2017 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | Spanish |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/17593 |
| Online Access: | https://hdl.handle.net/20.500.14352/17593 |
| Access Level: | Open access |
| Keyword: | 66 546 615.46 Mesoporous nanoparticles PH-responsive Cancer Stimuli-responsive Materiales Química inorgánica (Química) 3312 Tecnología de Materiales 2303 Química Inorgánica |
| Summary: | The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents. |
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