Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery
A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new materi...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/17591 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/17591 |
| Access Level: | acceso abierto |
| Palabra clave: | 66 546 615.46 Biomaterials Polymers Materiales biomédicos Polímeros Materiales Química inorgánica (Química) 3312 Tecnología de Materiales 2303 Química Inorgánica |
| Sumario: | A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment. |
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