Regulation of Piezo1 channels and its impact on cell division

This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of forces occurring during cytokinetic abscission. In this context, we have disco...

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Detalles Bibliográficos
Autor: Carrillo García, Julia
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/672669
Acceso en línea:http://hdl.handle.net/10803/672669
Access Level:acceso abierto
Palabra clave:Mechanotransduction
Piezo1
Pascin3
Membrane dynamics
Cytokinesis
Mecanotransducción
Dinámicas de membrana
Citocinesis
576
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oai_identifier_str oai:www.tdx.cat:10803/672669
network_acronym_str ES
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repository_id_str
spelling Regulation of Piezo1 channels and its impact on cell divisionCarrillo García, JuliaMechanotransductionPiezo1Pascin3Membrane dynamicsCytokinesisMecanotransducciónDinámicas de membranaCitocinesis576This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of forces occurring during cytokinetic abscission. In this context, we have discovered that the Piezo1 channel is regulated during cell division to integrate biochemical and physical cues, orchestrating the recruitment of the abscission machinery and mediating vesicle trafficking to the midbodyEste proyecto ha tenido por objetivo investigar la regulación de canales mecanosensibles Piezo1 por proteínas encargadas de sensar y modificar la curvatura de la membrana. Nuestro segundo objetivo ha sido estudiar esta relación en el contexto de las fuerzas que imperan la abscisión de las células hijas durante la citocinesis. En este contexto, hemos descubierto que el canal Piezo1 está regulado durante la división celular para integrar señales físicas y bioquímicas, orquestando el reclutamiento de la maquinaria de abscisión y mediando el tráfico de vesículas al puente intercelular.Programa de doctorat en BiomedicinaValverde, M. A. (Miguel Ángel)Fernández-Fernández, José ManuelUniversitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut202120222021info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion202 p.application/pdfapplication/pdfhttp://hdl.handle.net/10803/672669TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6726692026-06-14T12:46:07Z
dc.title.none.fl_str_mv Regulation of Piezo1 channels and its impact on cell division
title Regulation of Piezo1 channels and its impact on cell division
spellingShingle Regulation of Piezo1 channels and its impact on cell division
Carrillo García, Julia
Mechanotransduction
Piezo1
Pascin3
Membrane dynamics
Cytokinesis
Mecanotransducción
Dinámicas de membrana
Citocinesis
576
title_short Regulation of Piezo1 channels and its impact on cell division
title_full Regulation of Piezo1 channels and its impact on cell division
title_fullStr Regulation of Piezo1 channels and its impact on cell division
title_full_unstemmed Regulation of Piezo1 channels and its impact on cell division
title_sort Regulation of Piezo1 channels and its impact on cell division
dc.creator.none.fl_str_mv Carrillo García, Julia
author Carrillo García, Julia
author_facet Carrillo García, Julia
author_role author
dc.contributor.none.fl_str_mv Valverde, M. A. (Miguel Ángel)
Fernández-Fernández, José Manuel
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
dc.subject.none.fl_str_mv Mechanotransduction
Piezo1
Pascin3
Membrane dynamics
Cytokinesis
Mecanotransducción
Dinámicas de membrana
Citocinesis
576
topic Mechanotransduction
Piezo1
Pascin3
Membrane dynamics
Cytokinesis
Mecanotransducción
Dinámicas de membrana
Citocinesis
576
description This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of forces occurring during cytokinetic abscission. In this context, we have discovered that the Piezo1 channel is regulated during cell division to integrate biochemical and physical cues, orchestrating the recruitment of the abscission machinery and mediating vesicle trafficking to the midbody
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/672669
url http://hdl.handle.net/10803/672669
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 202 p.
application/pdf
application/pdf
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424919379443712
score 15,301603

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