Regulation of Piezo1 channels and its impact on cell division
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of forces occurring during cytokinetic abscission. In this context, we have disco...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/672669 |
| Acceso en línea: | http://hdl.handle.net/10803/672669 |
| Access Level: | acceso abierto |
| Palabra clave: | Mechanotransduction Piezo1 Pascin3 Membrane dynamics Cytokinesis Mecanotransducción Dinámicas de membrana Citocinesis 576 |
| Sumario: | This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of forces occurring during cytokinetic abscission. In this context, we have discovered that the Piezo1 channel is regulated during cell division to integrate biochemical and physical cues, orchestrating the recruitment of the abscission machinery and mediating vesicle trafficking to the midbody |
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